… activity with respect to one or more substrates or decreased transporter selectivity (22–25)…
alter the metal transport profile of a ZIP family member. One example of how such transporters …

… Arabidopsis chimeric transporters, we show that a small region of five residues in the His-rich
loop is responsible for selectivity … the two proteins were changed with the equivalent ones …

… To determine whether a more neutral pH would alter uptake rates, we tested uptake at pH
… Zinc uptake activity in Arabidopsis ZIP transporters has also been found to be pH dependent…

… or Asp, respectively, and the metal selectivity of the mutated transporters was assessed in the
yeast … In DraNRAMP, the M230A mutation did not alter Fe, Mn, and Co transport activity, but …

… that NRAMP1 has a broad selectivity in vivo. The role of transporters of the NRAMP family
is … is a consequence of an alteration of the plant Mn content, we measured metal content by …

… Dicotyledonous plants, such as the model plant Arabidopsis thaliana, rely on a multistep iron
… metals only secondary substrates resulting from its poor selectivity. These non-iron heavy …

… CAX genes may have enhanced selectivity for Cd 2+ , or may be altered (engineered, or …
selective enzymes were retained, or perhaps Ca 2+ binding to a single transporter was altered …

… transporters that have been studied in heterologous systems exhibit low selectivity in the
metal … Control plants were grown on a modified Gamborg's B-5 medium containing full-strength …

… His was changed to Gln, as this is a relatively conservative change that would impair
metal binding, while Lys was changed to Arg, as both amino acids are basic and this change …

… Samples in which the Cys residues were oxidized or modified by acetamide exhibited no …
Metal selectivity in biology is complex and poorly understood in detail, but it seems that a …