… However, the UPR is a double-edged sword; if the stress is … treatment does not modify
autophagy degradation. Thus, these … and XBP1s supports a therapeutic potential of the IRE1-UPR …

… autophagy may promote protein degradation and provide an effective disease-modifying
therapy for neurodegenerative diseases… Autophagy is a double-edged sword in cancer, either …

… Abstract: Autophagy is a catabolic process that degrades dysfunctional proteins and … , it
is worth noting that autophagy is considered a “double-edged sword”. Triple negative breast …

… diseases, where they respond as a double-edged sword, depending on the severity of injuries
and the nature of the diseases (… of autophagy in various neurodevelopmental disorders in …

… Although autophagy has no unified role in cerebral ischemia, increasing evidence supports
the notion that autophagy is a double-edged sword. We believe that the degree of autopha…

… to explore the therapeutic potential of SIRT2 manipulation for … of these disorders, suggesting
that regulation of autophagy … of substrates are also a double-edged sword when it comes to …

… Indeed, the use of drugs targeting such a crucial pathway could function as a double-edged
sword. For example, molecules that irreversibly activate the Wnt signaling might be …

… Hypoxia-induced autophagy in endothelial cells: a double-edged sword in the … Meyer, GR
Autophagy in atherosclerosis: a cell survival and death phenomenon with therapeutic potential.…

… It remains to be determined how autophagy homeostasis can be maintained in the pathological
state and how this double-edged sword can be utilized to beneficial effect. In addition, …

… maintained by the autophagy-lysosomal pathway. … , and particularly on the therapeutic potential
of targeting lysosomes, … Mitophagy is considered to be a double-edged sword in cerebral …