… recommended treatment plan is radical surgery combined … could inhibit abnormal activation
of the Ras/Raf/Mek/Erk pathway, … Targeting of melanoma brain metastases using engineered …

… in combination with Trametinib is approved for first-line … BRAF作为RAS-RAF-MEK-ERK通路
的上游调节因子，参与丝裂… Paradoxical activation and RAF inhibitor resistance of BRAF …

… a B-raf inhibitor that is currently used to treat melanoma, was … the treatment of melanoma, it
might be repurposed for stroke … a B-Raf/MEK/ERK-sensitive signaling pathway. BMC Neurosci …

… when we are still exploring the better targeted therapies for … 免疫检查点抑制剂（immune
checkpoint inhibitor, ICI）目前是另… 家族 [8] ，是RAS-RAF-MEK-ERK通路的上游调节因子，参与丝裂…

… 异常表 达,包括经典的RAF/MEK/ERK以及PI3K/AKT/mTOR信号 … Hsp90 molecular chaperone
inhibitors :are we there yet?[J]. … BRAF inhibitor resistance in melanoma via targeted inhibition …

… The RAS-RAF-MEK-ERK pathway is one of the most … We further hypothesize that a novel
treatment for metastatic MSS … The first is the combination of a complement inhibitor (ideally, C3a …

… found to inhibit mTOR with low toxicity and less side effects. In this paper, we reviewed
the … 生长因子通过激活PI3K/Akt 和Ras-Raf-MEK-ERK 通路,可抑制结节性硬化复合物Ⅱ(TSC2)磷酸…

… achieved due to the progression of early diagnosis and precision medicine at recent years,
however, until now, treatments … 原激活物抑制因子1（plasminogen activator inhibitor-1, PAI-1）…

… Second, to inhibit over-expressed genes. Third, to introduce … , IIH or the combination treatments
in a transgenic … or without combination of hyperthermia against malignant melanoma. The …

… Small-molecule inhibition of Wnt signaling through activation of casein kinase 1alpha. …
Inhibition of the Wnt/beta-catenin signaling pathway improves the anti-tumor effects of sorafenib …