Cortical-subcortical structural connections support transcranial magnetic stimulation engagement of the amygdala
The amygdala processes valenced stimuli, influences emotion, and exhibits aberrant activity
across anxiety disorders, depression, and PTSD. Interventions modulating amygdala activity
hold promise as transdiagnostic psychiatric treatments. In 45 healthy participants, we
investigated whether transcranial magnetic stimulation (TMS) elicits indirect changes in
amygdala activity when applied to ventrolateral prefrontal cortex (vlPFC), a region important
for emotion regulation. Harnessing in-scanner interleaved TMS/functional MRI (fMRI), we …
across anxiety disorders, depression, and PTSD. Interventions modulating amygdala activity
hold promise as transdiagnostic psychiatric treatments. In 45 healthy participants, we
investigated whether transcranial magnetic stimulation (TMS) elicits indirect changes in
amygdala activity when applied to ventrolateral prefrontal cortex (vlPFC), a region important
for emotion regulation. Harnessing in-scanner interleaved TMS/functional MRI (fMRI), we …
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