蛋白質合成和蛋白酶體降解作用之正調控賦予非典型橫紋肌樣瘤對蛋白酶體抑製劑萬科(Bortezomib) 之敏應性

TM Huy - 臺北醫學大學國際醫學研究博士學位學程學位論文, 2020 - airitilibrary.com
… Administration approved proteasome inhibitor bortezomib (BTZ) as … We performed differential
gene expression and gene set … effect of BTZ was evaluated in three human ATRT-MYC cell

聚集小体-聚集自噬转变过程: 越来越接近HDAC6 和BAG3 的功能作用

H Körschgen, C Behl - 中国神经再生研究(英文版), 2024 - sjzsyj.com.cn
… such as MG-132, bortezomib, lactalysin, or epoxomicin. In … a compensatory mechanism upon
proteasome inhibition has been … , now enable a substantially differentiated analysis of these …

蛋白酶体在信号转导和神经退行性疾病中的作用

JJ Chen, F Lin, ZH Qin - Neuroscience Bulletin, 2008 - Springer
… form of human SOD[60]. These cells were more sensitive to proteasome inhibition, which …
clinical use based on inhibition of the UPS is bortezomib, a proteasome inhibitor that blocks the …

蛋白酶体抑制剂MG132 对卵巢癌作用机制的研究现状

岳驰, 刘辉, 刘星辰, 魏宝宝… - 中华妇幼临床医学杂志 …, 2018 - zhfylcyxzz.cma-cmc.com.cn
… Research status on mechanism of proteasome inhibitor MG132 on ovarian cancer[J]. Chinese
Journal of Obstetrics & Gynecology and Pediatrics(Electronic Edition), 2018, 14(06): 629-…

海洋天然物做為抗癌藥物之研究

黃俊嵐, 梁美智 - 2012 - ir.lib.nycu.edu.tw
… The 26S proteasome inhibitor bortezomib, has … by bortezomib in a human multiple myeloma
cell line. This result supports our hypothesis that prodigiosin might be an IKKβ inhibitor. For …

[HTML][HTML] 细菌蛋白酶体及蛋白酶体抑制剂研究进展

孔啸鸣, 刘明皓, 黄英 - 微生物学报, 2023 - actamicro.ijournals.cn
… processes and guides the mining of proteasome inhibitors (PI) with broad medical … first
proteasome inhibitor put into clinical use belongs to this catagory [84, 90] Bortezomib 1 …

酶消化细胞团块法对人胚胎干细胞中OCT4 与SOX2 蛋白水平的影响

孙潇智, 李爽, 金颖, 廖兵 - 上海交通大学学报(医学版), 2021 - xuebao.shsmu.edu.cn
… 团块法对人胚胎干细胞(human embryonic stem cell,hESC)的八聚体… proteasome inhibitor
(bortezomib) and lysosome inhibitor (… staining to measure their effects on COL4-induced down …

[HTML][HTML] 去泛素化酶小分子抑制剂抗肿瘤作用研究: 新进展和新思路

刘湘宁, 杜佳泯, 钱美佳, 董晓武, 杨波, 朱虹, 何俏军 - 药学学报, 2022 - html.rhhz.net
… 其中, 针对蛋白酶体抑制剂的研究进展最快, 目前被FDA批准的蛋白酶体抑制剂有bortezomib,carfilzomb和
ixazomb [11, 12] , 已上市并被用于多发性骨髓瘤和套细胞淋巴瘤的治疗.蛋白酶体…

[HTML][HTML] 硼替佐米对大鼠肝纤维化动物模型NF-κB 和TGF-β1 表达的调控

潘雯, 陈旭平, 苏松, 陶中桦 - 世界华人消化杂志, 2015 - wjgnet.com
… AIM: To assess the protective effect of the proteasome inhibitor bortezomib on liver fibrosis
… κB抑制蛋白(inhibitor of κB, IκB)的表达来抑制NF-κB的活性[1,2]. 硼替佐米(bortezomib, Bor)是一…

以動態磷酸化蛋白體學探討異位表達ATP 合成酶抑制劑黃綠青黴素在艾瑞莎抗藥性肺癌細胞中所扮演的角色

XJ Chen - 國立臺灣大學分子與細胞生物學研究所學位論文, 2016 - airitilibrary.com
… to 174 phosphorylated proteins significantly differential expressed. Functional enrichment …
, cell cycle and apoptosis. Interestingly, we found that citreovirdin suppressed cell proliferation …