The Compton camera can simultaneously acquire images of multiple isotopes injected in a body; therefore, it has the potential to introduce a new subfield in the field of biomedical imaging applications. The objective of this study is to assess the ability of a prototype semiconductor-based silicon/cadmium telluride (Si/CdTe) Compton camera to simultaneously image the distributions of technetium (99m Tc)-dimercaptosuccinic acid (DMSA)(141 keV emission) and 18 F-fluorodeoxyglucose (FDG)(511 keV emission) injected into a human volunteer.