… Increased vulnerability of hippocampal neurons to excitotoxic necrosis in presenilin-1 mutant
knock… Val97Leu mutant presenilin-1 induces tau hyperphosphorylation and spatial memory …

… search: oligodendrocyte, tumor necrosis factor α, interleukin, … Expressions of mutant
presenilin-1 and exposure … This cytokine could directly induce neuronal excitotoxicity through …

… mediated by NLRP1 in primary cortical neurons; RNA interference-mediated knockdown of
… )/presenilin 1 (PS1) mice significantly reduced neuronal pyroptosis and improved cognitive …

… that initiates both apoptosis and necrosis. Adult … Motoneurons expressing mutant SOD1
showed an early increase in … sporadic AD and presenilin 1 (PSEN1) mutant fibroblasts via its …

… mutant proteins amyloid precursor protein and presenilin-1, loss of GFAP and VIM lead to
major increases in Aβ plaque load and neuron … death through release of tumor necrosis factor-…

… to proteasomal degradation pathogenic mutation or knockdown of … of neurons through more
complex pathways such as the activation of glycogen synthase kinase 3-beta by presenilin-1 …

… -1α),肿瘤坏 死因子α (tumor necrosis factor α, TNFα) 等炎性因子 均… is associated with increased
hippocampal activity, atrophy … Amyloid β, glutamate, excitotoxicity in Alzheimer's disease: …