… 在發育過程中,藉由基因甲基化修飾(DNA methylation)… Dnmt1 in zebra fish embryos caused
defects in terminal differentiation of the pancreas, furthermore, losing catalytic activity of Dnmt1 …

… carbon atom of cytosine catalyzed by DNMT1,DNMT3A and DNMT3B,… of mammalian DNA
methylation,and the role of DNA … demethylation :1)passive dilution,ie,DNA replication or loss …

… underlying the differentiation and function of pancreatic β cells. Key words: epigenetics; …
Loss of Dnmt1 catalytic activity reveals multiple roles for DNA methylation during pancreas …

… DNA methylation has been demonstrated to be required for vertebrate early embryogenesis.
Loss … , Uhrf1 蛋白的SRA区可以结合到半甲基化的DNA上, 招募Dnmt1, 并与Dnmt1 形成复合体.…

… cells did, while there was a decrease in DNA methylation level as … To evaluate whether loss
of pluripotency occurred during … of DNMT1 and a decrease in global CpG island methylation …

… into target DNA and attach to DNMT1 during DNA replication … In contrast, the loss function
of HDAC7 leads to the increased … expression by deleting DNA methylation at the promoter …

… lost, creating an uncovered singlestranded fragment of DNA … functions in almost the entire
process, from pancreas … may be regulated by various mechanisms such as DNA methylation, …

… remains because of lack of loss-off function animal modal to dissect Daxx function in vivo. It
… and Daxx mutation frequently occurs in pancreatic neuroendocrine tumors (PanNETs) – a …

… In this review, we summarize the advances on the epigenetic regulation during zygotic
genome activation in zebrafish, including DNA methylation, histone modification and nucleosome …

… of cruciferous vegetables, sensitized pancreatic adenocarcinoma cells to … There are three
main DNMTs: DNMT1, which is the major … Similar to DNA methylation changes, various histone …