Molecular response and cooperative behavior during the interactions of melittin with a membrane: dissipative quartz crystal microbalance experiments and …
N Lu, K Yang, B Yuan, Y Ma - The Journal of Physical Chemistry …, 2012 - ACS Publications
The molecular-level interactions of an antimicrobial peptide melittin with supported
membrane were studied by the combination of dissipative quartz crystal microbalance (QCM-
D) experiments and computer simulations. We found the response behavior of lipids upon
peptide adsorption greatly influence their interactions. The perturbance and reorientation of
the lipid in liquid phase facilitate the insertion of melittin in a trans-membrane way, but in
solid phase, asymmetrical membrane disruption happens. Apart from the lipid state, the local …
membrane were studied by the combination of dissipative quartz crystal microbalance (QCM-
D) experiments and computer simulations. We found the response behavior of lipids upon
peptide adsorption greatly influence their interactions. The perturbance and reorientation of
the lipid in liquid phase facilitate the insertion of melittin in a trans-membrane way, but in
solid phase, asymmetrical membrane disruption happens. Apart from the lipid state, the local …
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