Urban living environments are known to influence human well-being and health; however, little is known about the multidimensionality of different environmental burdens. The aim of this study is to examine the relations between multiple burdens and self-rated health of city residents in Berlin. A spatial analysis was conducted to determine neighborhood street blocks with high versus low levels of three environmental burdens (traffic noise, air pollution, lack of public green space) as study sites for a cross-sectional household questionnaire. Burden level served as a dichotomous predictor to compare residents' self-reports of neighborhood satisfaction, life satisfaction, health behavior, and psychological and physical health symptoms. Residents from high-burden blocks appraised the environmental conditions more stressful, reported poorer health behavior and were less satisfied with their neighborhood than residents from low-burden blocks. However, they did not differ in regard to more general health symptoms. Three other burdens (behavior-related noise, litter and dirt in public space, lack of urban vegetation), which could not be varied objectively, were assessed by their perceived intensity. Regression analyses of the relations between the perceived levels of all six burdens and outcomes in the total sample revealed the following: Neighborhood satisfaction could be predicted from multiple stressors and resources that co-occur independently, while more general health symptoms were related only to perceived air pollution. The results have implications for both urban planning and public health.