Background Epigenetic signatures in the nasal epithelium, which is a primary interface with
the environment and an accessible proxy for the bronchial epithelium, might provide insights
into mechanisms of allergic disease. Objective We aimed to identify and interpret
methylation signatures in nasal epithelial brushes associated with rhinitis and asthma.
Methods Nasal epithelial brushes were obtained from 455 children at the 16-year follow-up
of the Dutch Prevention and Incidence of Asthma and Mite Allergy birth cohort study …