Variable effects of gender and W estern diet on lipid and glucose homeostasis in aged PCSK9‐deficient C57BL/6 mice 性别与西方饮食对CSK9 基因缺陷的PC57BL/6 …
…, F Sirois, C Gyamera‐Acheampong… - Journal of …, 2015 - Wiley Online Library
… What this study adds: While loss-of-function PCSK9 genetic … Plasma LDL-C lowering is a
dominant phenotype of this … genotype with a PCSK9 loss-of-function mutation is associated with …
dominant phenotype of this … genotype with a PCSK9 loss-of-function mutation is associated with …
Proprotein C onvertases S ubtilisin/K exin T ype 9, an enzyme turned escort protein: Hepatic and extra hepatic functions (第9 型前蛋白转换酶—枯草溶菌素/蛋白酶K, 一 …
… as a target for a new-generation of hypocholesterolemic … of plasma LDL-C and lower plasma
cholesterol levels;113 (iii) … of loss-of-function natural PCSK9 mutations provided insight into …
cholesterol levels;113 (iii) … of loss-of-function natural PCSK9 mutations provided insight into …
Short-and long-term effects of Xuezhikang (血脂康), an extract of cholestin, on serum proprotein convertase subtilisin/kexin type 9 levels
… lipoprotein cholesterol (LDL-C) in hepatocytes,(6) PCSK9 … its loss-of-function mutations
are associated with reduction in … Plasma Levels of PCSK9 and Lipid Parameters As shown in …
are associated with reduction in … Plasma Levels of PCSK9 and Lipid Parameters As shown in …
[HTML][HTML] 降胆固醇药物新靶标前蛋白转化酶枯草溶菌素9 的研究进展
李昊， 陶龙啸， 章卫平 - 第二军医大学学报, 2017 - html.rhhz.net
… Proprotein convertase subtilisin/kexin type 9 as a new target of … -function-and loss-of-function-mutation
of PCSK9 have great … As a result, PCSK9 can reduce the efficiency of statins by …
of PCSK9 have great … As a result, PCSK9 can reduce the efficiency of statins by …
PCSK9 降解低密度脂蛋白受体分子机制研究进展
吴玉娴， 王琰 - 遗传, 2020 - chinagene.cn
… In this review, we will summarize the latest progress in the … PCSK9 reduces the protein levels
of the LDL receptor in mouse … The loss-of-function PCSK9 p.R46L genetic variant does not …
of the LDL receptor in mouse … The loss-of-function PCSK9 p.R46L genetic variant does not …
前蛋白转化酶枯草溶菌素9 基因多态性与新疆维维吾尔族和汉族人群腔隙性脑梗死易感性的关联与差异
D Han, J Ma, C Hao - 中国神经再生研究(英文版), 2017 - sjzsyj.com.cn
… loss of function nonsense mutations in PCSK9 and low levels of plasma low-density
lipoprotein and reduced … League Conference defined the new standard for the diagnosis of …
lipoprotein and reduced … League Conference defined the new standard for the diagnosis of …
PCSK9 抑制剂在脂代谢中的研究进展
刘壮， 耿雪梅， 柯永胜 - 大连医科大学学报, 2019 - journal.dmu.edu.cn
… LDLR from escaping lysosome digestion, thereby reduce cell surface LDLR density and
lead to the increase of plasma low density lipoprotein cholesterol (LDL-C). PCSK9 inhibitors …
lead to the increase of plasma low density lipoprotein cholesterol (LDL-C). PCSK9 inhibitors …
PCSK9 基因遗传规律与冠心病关系的研究进展
许嘉彬， 王立波， 陈伟达 - 解放军医学院学报, 2018 - xuebao.301hospital.com.cn
… The latest study finds that PCSK9 gene is related with coronary … of PCSK9 loss of function
variants on serum lipid and PCSK9 … PCSK9 gene R46L variant is associated with lower plasma …
variants on serum lipid and PCSK9 … PCSK9 gene R46L variant is associated with lower plasma …
[HTML][HTML] PCSK9 抑制剂在颈动脉狭窄中的应用进展
刘鑫， 刘佳 - Advances in Clinical Medicine, 2023 - hanspub.org
… 存在功能获得型(Gain Of Function, GOF)和功能缺失型(Loss Of Function, … LDL-C;2) PCSK9合成
抑制:在翻译水平上阻止PCSK9的形成,使PCSK9基因沉默;3) 自催化过程抑制:包括中断PCSK9…
抑制:在翻译水平上阻止PCSK9的形成,使PCSK9基因沉默;3) 自催化过程抑制:包括中断PCSK9…
[HTML][HTML] PCSK9 抑制剂在脂质代谢和动脉粥样硬化中的应用
刘扬， 罗健 - Advances in Clinical Medicine, 2023 - hanspub.org
… risk-reducing effects, and have been used as a new type of li-pid-lowering drugs in … 的
第一个也可能是研究最多和最重要的靶点是肝细胞表面的LDL-R,PCSK9通过与LDL-C和LDL…
第一个也可能是研究最多和最重要的靶点是肝细胞表面的LDL-R,PCSK9通过与LDL-C和LDL…