… In recent years, most of the related applications are focused on developing complex drugs,
and most of the few reported analysis methods are liquid chromatography-tandem mass …

Endophytes attracted much attention in exploitation of novel products and regulation of host
plant physiology, development and metabolism in recent twenty years, which have become …

Multiscale models and simulations play a significant role in the" Materials Genome Initiative".
This article reviews computational methods at spatial scale from quantum to microscopy, …

… 14-3-3s regulates a variety of biological functions through protein-protein interactions, such
… selected as a target to screen for natural product inhibitors of protein-protein interactions. …

Objective: Identifying lung cancer disease-related functional modules is important to
understand the mechanism of lung cancer. Methods: In this paper, we propose an integration …

… important implications for drug development and the … in PROTAC technology in terms of
protein degradation, drug … , and harmful proteins by recruiting E3 ligases to target proteins, …

… Moreover, we will address novel approaches that are based … target proteins. We want to
focus our interest on proteolysis… it an important target for drug development. By degrading both …

… targeting chimera (PROTAC) technique is an newly-emerging strategy to chemically induce
the target protein degradation … momentum in the field of drug discovery. The present review …

… a target protein to a CRL E3 via a chemical linker to trigger the degradation of target protein.
… PROTAC has become a hotspot in the field of E3-ligase-based anti-cancer drug discovery. …