琥珀酰化修饰: 脑卒中的潜在治疗目标

J Lian, W Liu, Q Hu, X Zhang - 中国神经再生研究(英文版), 2024 - sjzsyj.com.cn
… play a significant role in mitochondrial energy metabolism after … Unlike protein acetylation
by acetyl-CoA, which is highly pH-… of cardiolipin under reversible lysine acylation (Zhang et al., …

糖尿病视网膜病变的表观遗传学修饰和代谢记忆机制

DD Liu, CY Zhang, JT Zhang, LM Gu, GT Xu… - 中国神经再生研究 …, 2023 - sjzsyj.com.cn
… by elevating the enzyme activity and transcripts of lysine-specific … mitochondrial NAD+/ NADH
ratios and increased acetyl-CoA … pivotal field, and reversible epigenetic modifications might …

[HTML][HTML] 蛋白质赖氨酸乙酰化修饰对中间代谢的调控研究

赖木兰, 陈雪岚 - 中国生物工程杂志, 2017 - html.rhhz.net
… The reversible lysine acetylation at specific sites of protein … 发现了乙酰化转移酶(acetyl-CoA
acetyltransferase 1,ACAT1),且… of the lysine acetylome in mitochondria identifies substrates of …

[HTML][HTML] 赖氨酸乙酰化的研究进展及应用

杨雨薇, 尚爽, 胡卓伟, 花芳 - 药学学报, 2019 - html.rhhz.net
… has deepened our understanding of lysine acetylation. … (KATs) with acetyl-CoA as a
cofactor and reversed by lysineAcetylation of mitochondrial proteins by GCN5L1 promotes …

[HTML][HTML] 细菌体内乙酰化修饰研究进展

刘婧, 李淑娴, 邵雷 - 微生物学通报, 2021 - wswxtb.ijournals.cn
Reversible lysine acetylation controls the activity of the mitochondrial enzyme acetyl-CoA
synthetase 2[J]. Proceedings of the National Academy of Sciences of the United States of …

蛋白质乙酰化修饰研究进展

吕斌娜, 梁文星 - 生物技术通报, 2015 - biotech.aiijournal.com
Acetylation is catalyzed by lysine acetyltransferases and … 细菌中,它可以由乙酸盐和辅酶A 经
乙酰 辅酶A 合成酶(acetyl-CoA synthase,ACS)催化得到, 从而参与脂质合成和产生能量等过程. 在…

[PDF][PDF] 乙酰辅酶A 合成酶2 在肿瘤发生发展中的研究进展

杨赟, 陈德玉 - 新医学, 2021 - xinyixue.cn
… According to the Warburg effect,tumor cells can not produce acetyl CoA by oxidative …
Reversible lysine acetylation controls the activity of the mitochondrial enzyme acetyl-CoA

MPT0E028 在人類大腸直腸癌與B 細胞淋巴癌之抗癌機轉探討

黃瀚立 - 2015 - tdr.lib.ntu.edu.tw
… Identified acetylated non-histone proteins demonstrate that reversible lysine acetylation
affects mRNA stability, and the localization, interaction, degradation and function of proteins (…

从翻译后修饰角度解析人工合成途径与底盘细胞的适配性

尤迪, 叶邦策 - 合成生物学, 2020 - synbioj.cip.com.cn
… 赖氨酸乙 酰化(reversible lysine acylation, RLA)对乙酰 CoA合成… Acetyl-CoA synthetases of
Saccharopolyspora erythraea are … A synthetase is acetylated on multiple lysine residues by a …

[PDF][PDF] 乙酰化, 能量代谢与肉品品质的关联

邹波, 李春保 - 肉类研究, 2019 - rlyj.net.cn
Lysine acetylation is a dynamic and reversible protein post-translational modification, which
is universal in life and regulates … for the generation of acetyl-CoA and histone acetylation[J]. …