[PDF][PDF] SMAD 鄄4 Cooperates with TGF 鄄茁to Enhance PTEN Expression Upon The Inhibition of RAS/ERK Pathway in Gastric Carcinoma Cells

A Matloob, LN PAN, H PAN, J LU… - Progress in Biochemistry …, 2011 - researchgate.net
… and TGF-茁enhanced the expression of PTEN in 293T cells, while they suppressed PTEN …
RAS and RAS/MEK/ ERK signaling in SMAD-4 function in gastric cancer, we treated MGC-803 …

癌症相关性炎症与肿瘤微环境相关研究进展

魏智民, 孙玉发, 李刚, 刘哲峰, 焦顺昌 - 中国肿瘤临床, 2018 - cjco.cn
… 细胞(myeloid-derived suppressor cells,MDSCs),调节性T 细胞(regulatory T cells,Tregs)和其他
Smad4 signalling in T cells is required for suppression of gastrointestinal cancer[J]. Nature, …

[HTML][HTML] 中國傳統醫藥蒙古黃耆在HCT116 結腸癌細胞體外和體內實驗呈現腫瘤抑制作用

AL Tseng - 2016 - ir.lib.ncu.edu.tw
… course of treating colorectal cancer necessitates development of … administration of AM
suppresses chromosome organization, … SMAD4 levels and response to 5-fluorouracil in colorectal

[PDF][PDF] 胃癌干细胞研究进展

赵增明, 孙彦洵, 杨晓 - 生命科学研究, 2009 - smkx.hunnu.edu.cn
… The existence of gastric cancer stem cells has been proved,… Kim 等在小鼠Tr细胞特异性
剔除Smad4 导致胃肠道肿瘤的发生,… Notr ch signaling functions as a binary switch for the …

[HTML][HTML] Smad4 在肿瘤侵袭和转移中的作用

黄晓丹, 张发明, 季国忠 - 世界华人消化杂志, 2009 - wjgnet.com
… , cell survival, angiogenesis and immunosurveillance. The tumor suppressor gene Smad4
(… (TGF-β-Smad) signaling, which is a key pathway in cancer invasion and metastasis. This …

[HTML][HTML] 胃癌相关基因研究进展

于尚睿, 黄晓俊, 张亚萍 - 世界华人消化杂志, 2016 - wjgnet.com
… in the development of gastric cancer. Although some driver … in gastric cancer, the molecular
compositions of gastric cancerSMAD4可能参与HDGC, Takaku等[14]敲除位于小鼠SMAD4上…

miRNA-196a-5p 调控Smad4 表达对胃癌干细胞特性的影响

郭睿, 戴建峰, 罗玉明, 赵海明, 唐鹏 - 中国组织工程研究, 2018 - cjter.com
… by targeting Smad4 in the gastric cancer stem cells. miR-196a-… IL-8 to suppress the invasion
and migration of breast cancer. … -β/Smad signaling in CD44-positive gastric cancer cells. Lab …

骨形成蛋白信号通路中Smad4 和Smad7 在口腔鳞癌中的表达变化

刘端芹, 张君, 宋洪宁, 郑君, 王旭霞 - 上海口腔医学, 2013 - sjos.cn
… Expression of Smad4 and Smad7 of BMP signaling pathway … metastasis in colorectal cancer
a study matched for tumor depth and … DPC4, a candidate tumor suppression gene, is altered …

[HTML][HTML] 结直肠癌干细胞的研究进展

彭珊, 胡国清 - 世界华人消化杂志, 2016 - wjgnet.com
… 结直肠癌(colorectal cancer, CRC)是常见的消化系恶性肿瘤之… , related signaling pathways,
and clinical applications. … 研究[93]还发现, 在没有Smad4突变和PI3K活化同时发生的CRC中, …

[PDF][PDF] 结直肠癌小鼠模型研究进展

苗晋鑫, 宋韶鹤, 李秀敏 - 中国实验动物学报, 2020 - zgbjyx.cnjournals.com
colorectal cancer mouse model increases our understanding of human colorectal cancer
characteristics and cancer … [20] 将Smad4 突变引 入APCΔ716 小鼠导致局部侵袭性恶性腺癌而无…