Synthesis and evaluation of cyanine–styryl dyes with enhanced photostability for fluorescent DNA staining
PR Bohländer, HA Wagenknecht - Organic & Biomolecular Chemistry, 2013 - pubs.rsc.org
PR Bohländer, HA Wagenknecht
Organic & Biomolecular Chemistry, 2013•pubs.rsc.org… We recently found out that one representative of these dyes, the cyanine–indole–quinolinium
dye (CyIQ), exhibits not only an excellent brightness in the presence of nucleic acids but
also a photostability that is significantly better than that of fluorescein, BODIPY and thiazole
orange as covalently bound fluorescent DNA labels. Herein, we present the synthesis and
optical spectroscopy of a new set of cyanine–styryl dyes of the CyIQ type 1–12 with
significantly improved brightness, photostability and fluorescence intensity enhancement in …
dye (CyIQ), exhibits not only an excellent brightness in the presence of nucleic acids but
also a photostability that is significantly better than that of fluorescein, BODIPY and thiazole
orange as covalently bound fluorescent DNA labels. Herein, we present the synthesis and
optical spectroscopy of a new set of cyanine–styryl dyes of the CyIQ type 1–12 with
significantly improved brightness, photostability and fluorescence intensity enhancement in …
The photostability of cyanine–styryl dyes of the indole–quinolinium type can be significantly improved by structural variations while the excellent optical properties including the bright fluorescence in the presence of DNA can be maintained or even improved, too.
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