… an adaptive reaction known as the unfolded protein response (UPR), which aims to re-… Due
to the fact synaptic dysfunction are salient features of most neurodegenerative conditions, the …

… of neurodegenerative diseases: abnormal protein aggregation and synaptic dysfunction. …
ranging from neurodegenerative diseases to neurodevelopmental and psychiatric disorders …

… autophagy in AD: ER stress is regulated by three unfolded protein response (UPR) signaling
… Importantly, astrogliosis, synaptic dysfunction and neurodegeneration associated with tau …

… neurodegenerative disorders – Alzheimer’s and Parkinson’s diseases – are characterized
by synaptic dysfunction … mechanisms that contribute to neurodegeneration in these disorders …

… alterations detected in neurodegeneration caused by misfolded prion protein and discusses
common toxicity pathways identified across different neurodegenerative diseases. Thus, …

… a crucial role in neurodegeneration: fibrillar conformers act as a reservoir of soluble oligomeric
species, which are the toxic counterpart promptly triggering neuronal dysfunction. In order …

… and cellular mechanisms that lead to progressive neurodegeneration and cognitive decline.
A … Neuroinflammation, oxidative stress, mitochondrial dysfunction, and synaptic impairment …

… inhibiting unfolded protein response activation or inducing chaperone expression and activity).
This review focuses on the features of protein imbalance in neurodegenerative disorders …

… ) is a progressive neurodegenerative disease that … synaptic dysfunctions. In preclinical
models, it has been demonstrated that an obesogenic diet leads to loss of hippocampal synaptic …

… the role of the UPR was well characterized in the context of neurodegenerative disease, its
… Knowing that UPR impairment accounted for one of the main age-associated alterations in …