… the attempted clinical assays in amyotrophic lateral sclerosis. … on the importance of RNA
metabolism in ALS. While mutations … associated with altered expression of RNA-binding protein …

… ’s diseases, amyotrophic lateral sclerosis and frontotemporal … -43 is an RNA binding
protein that participates in RNA metabolism, … stable and avoiding its alteration could prevent …

… amyotrophic lateral sclerosis (ALS). … metabolism, and subsequently, to disrupted mRNA
splicing, the formation of aberrant RNA species in the cytoplasm, and ultimately to altered …

… RNA metabolism, altered endosomal trafficking, induction of oxidative stress and mitochondrial
malfunctions (Gao et al., … The pathophysiology of amyotrophic lateral sclerosis (ALS) is …

… Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative condition characterized by
… including aberrant RNA metabolism, glutamate-mediated excitotoxicity, impaired protein …

… Amyotrophic lateral sclerosis (ALS) is a progressive … failure (Hardiman et al., 2011; Kazamel
et al., 2013). A hallmark of … FRZB and FGF23, both secreted factors, were not altered in ALS …

… dismutase 1-amyotrophic lateral sclerosis patients. Literature … From these case series of
cognitively impaired SOD1-ALS … This study provided evidence for differences in metabolic …

… include amyotrophic lateral sclerosis (ALS), Parkinson’s disease (PD), multiple sclerosis (…
of established risk factors on the alteration of metabolism in relation to the development of …

… and consolidation (Creighton et al., 2020). The epigenome is altered in the aging brain, …
metabolism, a key metabolic pathway that couples the folate and methionine cycles. Dietary …

… the available literature on impaired mtDNA methylation in neurodegenerative … al., 2022),
and our evidence that among carriers of the major genes causing amyotrophic lateral sclerosis…