… insulitis that leads to transient β-cell dysfunction.26, 27 Further studies have found that during
the “silent β-cell loss” stage, the loss of β-cell function … likely direct effects on inflammation, …

… inflammatory sites.38 A pathogenic role for CCL22 was hypothesized based on reduced
insulitis … of both the immune system and the pancreatic β-cell,7 we combined transcriptome and …

… These high-functioning T reg cells could limit inflammatory responses and anergize effector
… to delay diabetic progression and preserve β-cell function.39 The properties and function of …

… and inflammation, are key regulators of β-cell functional alternations. In this review, we
summarize the research progress on the β-cell … of humans with type 2 but not type 1 diabetes. …

… This view was based on three observations: (i) PCSK9 transcripts are found in substantial
amounts in pancreatic β cell lines,1 (ii) LDLR is expressed in pancreatic β cells and can …

… islet β-cell is adjacent to an islet capillary, where the β-cell can … vasculature can regulate
endocrine islet function.7 Therefore, the … These mice were used to exclude any effects of insulitis …

… through interaction of cytokines and inflammatory cells[2]. … with the primary feature of β-cell
damage under the effects of … development of insulitis. J Immunol. 2005;174(2):680-687. …

… The role of inflammation in insulitis and β-cell loss in type 1 diabetes[J].Nat Rev
Endocrinol,2009,… Autoimmunity and β cell regeneration in mouse and human type 1 diabetes …