6 类精神药物对临床前及早期阿尔茨海默病, 帕金森病, 亨廷顿病及其他神经退行性疾病的意义

EC Lauterbach - 中国神经再生研究(英文版), 2016 - sjzsyj.com.cn
… and memantine (MMT) are displayed for specific steps in the … and entorhinal cortex neuronal
loss, reduced axonal … reduced AD pathology and cognitive deficits in a transgenic mouse. …

神经营养因子和阿尔茨海默病及帕金森病: 对发病机制和治疗的意义

TB Sampaio, AS Savall, MEZ Gutierrez… - 中国神经再生研究(英文 …, 2017 - sjzsyj.com.cn
… linked with several major pathological processes in AD, … Regarding AD, postmortem-derived
tissue show NGF levels … that AD transgenic mouse models show decreased cortical BDNF …

来自3xTg-AD 小鼠的永生化海马星形胶质细胞, 研究疾病相关星形胶质细胞功能障碍的新模型: 比较综述

L Tapella, G Dematteis, AA Genazzani… - 中国神经再生研究 …, 2023 - sjzsyj.com.cn
… astrocytes, and displayed glioblastoma multiforme phenotypes. … human AD pathology,
including severe synapse loss, followed … stress and Alzheimer’s disease-like pathology in human …

神经干细胞促进神经可塑性: 阿尔茨海默病一种有前景的治疗策略

J Chang, Y Li, X Shan, X Chen, X Yan, J Liu… - 中国神经再生研究(英文 …, 2024 - sjzsyj.com.cn
… Nerve growth factor (NGF) exerts neurotrophic activity, … These aged mice are known to
exhibit concentrations of Aβ40 … ameliorates Alzheimer’s disease-like pathology in a mouse

神经可塑性和脑退化机制: 衰老过程中的保护策略

M Toricelli, AAR Pereira, GS Abrao… - 中国神经再生研究 …, 2021 - sjzsyj.com.cn
… binding of BDNF and NGF neurotrophins to their respective … their impairment may contribute
to Alzheimer’s pathology. It is … (Li2CO3) can reduce neuronal loss in the hippocampus and …

Cdk5 与神经退行性变核心的异常细胞周期激活

R Requejo-Aguilar - 中国神经再生研究(英文版), 2023 - sjzsyj.com.cn
… However, under pathological conditions, Cdk5 dysregulation … Thus, a decrease of nerve
growth factor (NGF) induces cyclin D1 … while mice overexpressing p25 displayed neuronal death …

胶质细胞源性神经营养因子和细胞重编程对海马相关神经系统疾病的治疗潜力

P Chiavellini, M Canatelli-Mallat, M Lehmann… - 中国神经再生研究 …, 2022 - sjzsyj.com.cn
… Epileptic rodents show patterns of neuronal loss and synaptic … unique pathological
modification of histone in depressed humans. Animals were studied under the paradigm of chronic

L-正缬氨酸: 一种对抗阿尔茨海默病的新型药物

B Polis, KD Srikanth, V Gurevich, H Gil-Henn… - 中国神经再生研究 …, 2019 - sjzsyj.com.cn
… These animals exhibit a synaptic deficiency, plaque, and … Nerve growth factor (NGF) binding
to high affinity nerve growth … Alzheimer’s disease-like neuropathology in 3xTg-AD mice and …

谷胱甘肽过氧化物酶4 在阿尔茨海默病中的保护作用及治疗意义

Y Shen, G Zhang, C Wei, P Zhao, Y Wang… - 中国神经再生研究(英文 …, 2025 - sjzsyj.com.cn
… c-Gpx4 knockout mice exhibit embryonic death, suggesting … and neuronal loss in P301S
Tau transgenic mice by inhibiting … induces Alzheimer’s disease-like pathologies in mice: A new …

tau 截短体与阿尔茨海默病的发病机制

D Chu, X Yang, J Wang, Y Zhou, JH Gu… - 中国神经再生研究 …, 2024 - sjzsyj.com.cn
… functions of Tau truncation in physiological and pathological conditions, in this review, we …
Transgenic mice expressing a Tau mutant that cannot be cleaved by caspases at D421 exhibit