Tularemia in BALB/c and C57BL/6 mice vaccinated with Francisella tularensis LVS and challenged intradermally, or by aerosol with virulent isolates of the pathogen …
In order to begin understanding the immunological basis for immunity to tularemia, and to
establish a baseline for judging the efficacy of potential novel vaccines, the present study
examined the ability of the live vaccine strain of Francisella tularensis (F. tularensis) LVS, to
elicit immunity in mice against subsequent systemic and aerosol challenge with highly
virulent strains of the pathogen. The results show, that infection with LVS protects BALB/c
mice against systemic challenge with virulent Types A and B F. tularensis. In contrast …
establish a baseline for judging the efficacy of potential novel vaccines, the present study
examined the ability of the live vaccine strain of Francisella tularensis (F. tularensis) LVS, to
elicit immunity in mice against subsequent systemic and aerosol challenge with highly
virulent strains of the pathogen. The results show, that infection with LVS protects BALB/c
mice against systemic challenge with virulent Types A and B F. tularensis. In contrast …
Tularemia in BALB/c and C57BL/6 mice vaccinated with Francisella tularensis LVS and challenged intradermally, or by aerosol with virulent isolates of the pathogen …
CWX Chen WangXue, SH Shen Hua, A Webb… - 2003 - cabidigitallibrary.org
In order to begin understanding the immunological basis for immunity to tularaemia, and to
establish a baseline for judging the efficacy of potential novel vaccines, the present study
examined the ability of the live vaccine strain of Francisella tularensis (F. tularensis) LVS, to
elicit immunity in mice against subsequent systemic and aerosol challenge with highly
virulent strains of the pathogen. The results show, that infection with LVS protects BALB/c
mice against systemic challenge with virulent Types A and B F. tularensis. In contrast …
establish a baseline for judging the efficacy of potential novel vaccines, the present study
examined the ability of the live vaccine strain of Francisella tularensis (F. tularensis) LVS, to
elicit immunity in mice against subsequent systemic and aerosol challenge with highly
virulent strains of the pathogen. The results show, that infection with LVS protects BALB/c
mice against systemic challenge with virulent Types A and B F. tularensis. In contrast …
