Parkinson's disease
… Parkinson's disease is a neurological disorder with evolving layers of complexity. It has long
been … In this Seminar, we review these complexities and challenges of Parkinson's disease. …
been … In this Seminar, we review these complexities and challenges of Parkinson's disease. …
Parkinson's disease
AJ Lees, J Hardy, T Revesz - The Lancet, 2009 - thelancet.com
… It is characterised by the presence of severe pars-compacta nigral-cell loss, and accumulation
of aggregated α-synuclein in specific brain stem, spinal cord, and cortical regions. The …
of aggregated α-synuclein in specific brain stem, spinal cord, and cortical regions. The …
Pathoanatomy of Parkinson's disease
H Braak, E Braak - Journal of neurology, 2000 - Springer
… The damaged regions appear in red to illustrate the extent of the lesions which consistently
develop in the brains of patients with Parkinson’s disease. Both diagrams show the pathways …
develop in the brains of patients with Parkinson’s disease. Both diagrams show the pathways …
Parkinson's disease
AE Lang, AM Lozano - New England Journal of Medicine, 1998 - Mass Medical Soc
… box indicate the activity of the brain region as compared with the normal level of activity (Panel
A). Dashed lines and arrows indicate the dysfunctional nigrostriatal dopamine system in …
A). Dashed lines and arrows indicate the dysfunctional nigrostriatal dopamine system in …
[HTML][HTML] Parkinson's disease: mechanisms and models
W Dauer, S Przedborski - Neuron, 2003 - cell.com
… Palsy,” James Parkinson described the core … disease after Alzheimer's disease (AD). Although
more than a century passed before the central pathological feature of Parkinson's disease …
more than a century passed before the central pathological feature of Parkinson's disease …
Parkinson's disease
KA Jellinger - … : the molecular pathology of dementia and …, 2011 - Wiley Online Library
… Metabolic and functional abnormalities already occur in brain regions at early stages of
PD which are not accompanied by Lewy pathology [92,97] . This staging system often but not …
PD which are not accompanied by Lewy pathology [92,97] . This staging system often but not …
Copper pathology in vulnerable brain regions in Parkinson's disease
… ) and locus coeruleus (LC) and in nondegenerating brain regions in cases of Parkinson's
disease (PD) and appropriate healthy and disease controls. In PD and incidental Lewy body …
disease (PD) and appropriate healthy and disease controls. In PD and incidental Lewy body …
Biochemical aspects of Parkinson's disease
O Hornykiewicz - Neurology, 1998 - AAN Enterprises
… mechanisms resulting in the parkinsonian movement disorder, and that the … these brain
regions which, like the striatum, suffer DAergic deafferentation in PD. From observations in brain …
regions which, like the striatum, suffer DAergic deafferentation in PD. From observations in brain …
Transferrin and iron in normal, Alzheimer's disease, and Parkinson's disease brain regions
DA Loeffler, JR Connor, PL Juneau… - Journal of …, 1995 - Wiley Online Library
… Regional transferrin and iron concentrations were generally more highly correlated (Pearson's
correlation coefficient) in elderly controls than in Alzheimer's and Parkinson's disease. …
correlation coefficient) in elderly controls than in Alzheimer's and Parkinson's disease. …
… brain regions in Parkinson's disease supports the involvement of specific protein processing, energy metabolism, and signaling pathways, and suggests novel disease …
Y Zhang, M James, FA Middleton… - American Journal of …, 2005 - Wiley Online Library
… RNA expression analysis of three brain regions (the SN, … brain regions in order to assess
areas that are primarily affected, secondarily affected, or more remote from the initial disease …
areas that are primarily affected, secondarily affected, or more remote from the initial disease …
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