The role of DNA adducts in chemical carcinogenesis
RC Garner - … Research/Fundamental and Molecular Mechanisms of …, 1998 - Elsevier
… A number of different methods have been developed to detect and measure DNA adducts in
… agents on DNA adduct level. AMS has been used to measure DNA adducts in human tissue …
… agents on DNA adduct level. AMS has been used to measure DNA adducts in human tissue …
DNA adducts, mutations and cancer
K Hemminki - Carcinogenesis, 1993 - academic.oup.com
… in the identification of DNA adducts. A vivid history of … cell carcinomas lower frequencies
ofp53 mutations were noted, but dipyrimidine sites were overwhelming in basal cell carcinomas …
ofp53 mutations were noted, but dipyrimidine sites were overwhelming in basal cell carcinomas …
Relationships between DNA adduct formation and carcinogenesis.
JA Swenberg, FC Richardson… - Environmental …, 1985 - ehp.niehs.nih.gov
… Data suggest that no single adduct isresponsible for the initiation of chemical … of all
promutagenic DNA adducts and the extent of cell replication for each population of cells exposed …
promutagenic DNA adducts and the extent of cell replication for each population of cells exposed …
DNA adducts as exposure biomarkers and indicators of cancer risk.
MC Poirier - Environmental health perspectives, 1997 - ehp.niehs.nih.gov
… Quantitation of DNA adducts in human tissues has been achieved with highly sensitive …
based on adduct radiolabeling, antisera specific for DNA adducts or modified DNA, and/or adduct …
based on adduct radiolabeling, antisera specific for DNA adducts or modified DNA, and/or adduct …
DNA adducts as markers of exposure and risk
DH Phillips - … Research/Fundamental and Molecular Mechanisms of …, 2005 - Elsevier
… of DNA adducts by metabolically activated intermediates. Detecting the presence of DNA
adducts in … A large body of evidence demonstrates that DNA adducts are useful markers of …
adducts in … A large body of evidence demonstrates that DNA adducts are useful markers of …
Oxidative DNA base modifications and polycyclic aromatic hydrocarbon DNA adducts in squamous cell carcinoma of larynx
… between oxidative DNA lesions and aromatic DNA adducts, six modified DNA bases 5-hydro…
dine and the total level of PAH-related DNA adducts were measured in cancerous and the …
dine and the total level of PAH-related DNA adducts were measured in cancerous and the …
Mutation signature analysis identifies increased mutation caused by tobacco smoke associated DNA adducts in larynx squamous cell carcinoma compared with oral …
AP South, NY den Breems, T Richa, U Nwagu… - Scientific reports, 2019 - nature.com
… We identify that mutations linked to DNA adducts associated with tobacco smoke exposure
are … growth and increased susceptibility to mutations from tobacco carcinogen DNA adducts. …
are … growth and increased susceptibility to mutations from tobacco carcinogen DNA adducts. …
DNA adducts and cell cycle
HM Rabes - Journal of cancer research and clinical oncology, 1986 - Springer
… DNA adduct formation in the cell cycle is primarily dependent on cell cycle-related modulations
in the production of electrophilic ultimate carcinogens from inactive precursor compounds…
in the production of electrophilic ultimate carcinogens from inactive precursor compounds…
In vitro BPDE‐induced DNA adducts in peripheral lymphocytes as a risk factor for squamous cell carcinoma of the head and neck
D Li, PF Firozi, P Chang, LE Wang… - … journal of cancer, 2001 - Wiley Online Library
… 19, 20 In this study of squamous cell carcinoma of the head and neck, we provide further
supporting evidence that the BPDE-induced DNA adduct assay indeed has potential value as a …
supporting evidence that the BPDE-induced DNA adduct assay indeed has potential value as a …
DNA adducts-chemical addons
TR Rajalakshmi, N AravindhaBabu… - Journal of Pharmacy …, 2015 - journals.lww.com
… cell carcinoma of the … DNA adduct is a piece of DNA covalently bond to a chemical (safrole,
benzopyrenediol epoxide, acetaldehyde). This process could be the start of a cancerous cell. …
benzopyrenediol epoxide, acetaldehyde). This process could be the start of a cancerous cell. …
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