Chagas disease drug discovery: toward a new era
E Chatelain - Journal of biomolecular screening, 2015 - journals.sagepub.com
American trypanosomiasis, or Chagas disease, is the result of infection by the Trypanosoma
cruzi parasite. Endemic in Latin America where it is the major cause of death from …
cruzi parasite. Endemic in Latin America where it is the major cause of death from …
Advances in preclinical approaches to Chagas disease drug discovery
F Villalta, G Rachakonda - Expert opinion on drug discovery, 2019 - Taylor & Francis
… for drug discovery. Finally, we propose the use of artificial intelligence to accelerate drug
discovery in Chagas disease and … that need to be overcome in Chagas disease drug discovery. …
discovery in Chagas disease and … that need to be overcome in Chagas disease drug discovery. …
Why hasn't there been more progress in new Chagas disease drug discovery?
AB Vermelho, GC Rodrigues… - … on Drug Discovery, 2020 - Taylor & Francis
… Introduction: Chagas disease (CD) is a neglected disease caused by the protozoan parasite
… novel drug discovery, there has been no progress since the 1960s with the same two drugs, …
… novel drug discovery, there has been no progress since the 1960s with the same two drugs, …
Phenotypic screening approaches for Chagas disease drug discovery
E Chatelain, JR Ioset - Expert opinion on drug discovery, 2018 - Taylor & Francis
… new opportunities for drug discovery for Chagas disease. … In the last decade, discovery efforts
in Chagas disease have … of Chagas disease, have changed the drug discovery landscape. …
in Chagas disease have … of Chagas disease, have changed the drug discovery landscape. …
Challenges in Chagas disease drug discovery: a review
R Paucar, E Moreno-Viguri… - Current Medicinal …, 2016 - ingentaconnect.com
… CD drug discovery … disease from different points of view: eg, control of transmission, access
to diagnostics and treatment, patients care or the discovery and development of new drugs. …
to diagnostics and treatment, patients care or the discovery and development of new drugs. …
A new era for Chagas disease drug discovery?
M Keenan, JH Chaplin - Progress in medicinal chemistry, 2015 - Elsevier
… for Chagas disease … Chagas disease drug discovery. Advances in pre-clinical profiling
assays, the current compound landscape and progress towards the identification of new drug …
assays, the current compound landscape and progress towards the identification of new drug …
[HTML][HTML] Development of Trypanosoma cruzi in vitro assays to identify compounds suitable for progression in Chagas' disease drug discovery
LM MacLean, J Thomas, MD Lewis… - … tropical diseases, 2018 - journals.plos.org
… is a major issue for further drug discovery efforts. Our goal was to identify cell-based
assays that could differentiate current nitro-aromatic drugs nifurtimox and benznidazole from …
assays that could differentiate current nitro-aromatic drugs nifurtimox and benznidazole from …
[HTML][HTML] Drug discovery for Chagas disease should consider Trypanosoma cruzi strain diversity
B Zingales, MA Miles, CB Moraes, A Luquetti… - Memórias do Instituto …, 2014 - SciELO Brasil
… aspect of Chagas disease drug discovery: the … Chagas disease drug discovery programmes,
but we consider it to be a valuable component of the early assessment of promising drug …
but we consider it to be a valuable component of the early assessment of promising drug …
[HTML][HTML] Drug discovery for chagas disease: A viewpoint
JM Kratz - Acta tropica, 2019 - Elsevier
… drug discovery for CD are discussed. It provides a personal viewpoint based on multiple
discussions and collaborations with scientists from the Chagas community around the globe. …
discussions and collaborations with scientists from the Chagas community around the globe. …
Current advances in drug discovery for Chagas disease
CB Scarim, DH Jornada, RC Chelucci… - European journal of …, 2018 - Elsevier
… In this review, we have discussed the different drug discovery approaches used for Chagas
disease, as well as some drug targets explored in the last few years. In this context, we have …
disease, as well as some drug targets explored in the last few years. In this context, we have …
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