神经退行性疾病表观遗传学研究中因果关系评估的观点
P Koulousakis, A Tiane, N Hellings… - 中国神经再生研究 …, 2023 - sjzsyj.com.cn
… epigenetic editing tools such as CRISPR-dCas9 could be utilized. An interesting approach
would be to make use of the CRISPR-dCas9DNMT3a/TET1 tool to … with the epigenetic editing …
would be to make use of the CRISPR-dCas9DNMT3a/TET1 tool to … with the epigenetic editing …
CRISPR/Cas9 藉由基因體和表觀基因組的編輯精準地調節癌症幹細胞相關基因表達
謝宇鈞 - 清華大學分子與細胞生物研究所學位論文, 2018 - airitilibrary.com
… /Cas9-mediated genome and epigenome editing for precision … epigenetic remodeling,
researchers have mutated the nuclease domains of Cas9 to create a nuclease deficient(dCas9…
researchers have mutated the nuclease domains of Cas9 to create a nuclease deficient(dCas9…
[PDF][PDF] CRISPR-dCas9 转录调控系统及其在
李博文， 梁世倩， 白健， 秦鸿雁 - 生命科学, 2019 - lifescience.sinh.ac.cn
… Epigenome editing by a CRISPR-Cas9-based acetyltransferase activates genes from
promoters and enhancers. Nat Biotechnol, 2015, 33: 510-7 [27] Snowden AW, Gregory PD, Case …
promoters and enhancers. Nat Biotechnol, 2015, 33: 510-7 [27] Snowden AW, Gregory PD, Case …
酿酒酵母中基于CRISPR/dCas9 的基因转录调控工具的开发与应用
陈永灿， 张建志， 司同 - 生物技术通报, 2020 - biotech.aiijournal.com
… dCas9-based gene transcriptional regulation tools in S. cerevisiae,we described the regulation
of dCas9 … tune the expression levels of both dCas9 and gRNA components,discussed the …
of dCas9 … tune the expression levels of both dCas9 and gRNA components,discussed the …
CRISPR/Cas9 系统在基因组编辑中的优化与发展
滕小龙， 史硕博 - 合成生物学, 2023 - synbioj.cip.com.cn
… or catalytically deficient Cas9 (dCas9) in CRISPR … dCas9/nCas9 to bring about new functions
and applications in gene expression regulation, epigenome editing, and single base editing…
and applications in gene expression regulation, epigenome editing, and single base editing…
[HTML][HTML] CRISPR/Cas9 基因编辑技术在家畜育种新材料创制中的研究进展
王欢， 邹惠影， 朱化彬， 赵善江 - 畜牧兽医学报, 2021 - xml-data.org
… 当Cas9两个结构域(RuvC和HNH)都发生突变时,可以得到没有切割活性只有结合活性的dCas9蛋白
(nickase-dead Cas9,dCas9),而CRISPR/dCas9系统可以在不损伤基因组DNA的情况下,在…
(nickase-dead Cas9,dCas9),而CRISPR/dCas9系统可以在不损伤基因组DNA的情况下,在…
基因组编辑技术在精准医学中的应用
李爽， 杨圆圆， 邱艳， 陈彦好， 徐璐薇， 丁秋蓉 - 遗传, 2017 - chinagene.cn
… 核酸酶切割活性失活而得到 dCas9,dCas9 可以与不同蛋白形成融合蛋白,… Epigenome editing
by a CRISPR-Cas9-based … Highly specific epigenome editing by CRISPR-Cas9 repressors for …
by a CRISPR-Cas9-based … Highly specific epigenome editing by CRISPR-Cas9 repressors for …
CRISPR/Cas 基因编辑及其新兴技术在丝状真菌研究中的系统应用
陈盈盈， 刘扬， 史俊杰， 马俊英， 鞠建华 - 合成生物学, 2024 - synbioj.cip.com.cn
… Epigenome editing by a CRISPR-Cas9-based … CRISPR/dCas9-mediated epigenetic
modification reveals differential regulation … epigenome editing[J]. Cell, 2021, 184(9): 2503-2519.e17. …
modification reveals differential regulation … epigenome editing[J]. Cell, 2021, 184(9): 2503-2519.e17. …
[PDF][PDF] CRISPR-Cas9 技术在构建基因线路中的应用
谢海标， 刘宇辰， 黄卫人 - 生命科学, 2017 - lifescience.sinh.ac.cn
… dCas9 上面.其中,美国科学家 利用dCas9 融合具有抑制作用的KRAB 结构域后发 现,dCas9
的… Epigenome editing by a CRISPR-Cas9-based acetyltransferase activates genes from …
的… Epigenome editing by a CRISPR-Cas9-based acetyltransferase activates genes from …
[PDF][PDF] CRISPR/Cas9 的原理及其在疾病治疗中的研究进展
王亮， 赵同标 - 2017 - ir.ioz.ac.cn
… CRISPR/Cas9 与表观修饰dCas9 蛋白 与表观修饰酶融合后可以发挥表观调控的作用. 将dCas9
与人… Highly specific epigenome editing by CRISPR-Cas9 repressors for silencing of distal …
与人… Highly specific epigenome editing by CRISPR-Cas9 repressors for silencing of distal …