Multi-omics characterization of silent and productive HPV integration in cervical cancer
J Fan, Y Fu, W Peng, X Li, Y Shen, E Guo, F Lu, S Zhou… - Cell Genomics, 2023 - cell.com
… in a cohort of 106 CC patients, we demonstrate that HPV integration leading to expression
of fusion transcripts is associated with CC progression. Further, multidimensional integrative …
of fusion transcripts is associated with CC progression. Further, multidimensional integrative …
Multi‐omics data reveals novel impacts of human papillomavirus integration on the epigenomic and transcriptomic signatures of cervical tumorigenesis
X Zeng, Y Wang, B Liu, X Rao, C Cao… - Journal of Medical …, 2023 - Wiley Online Library
… characterize HPV integrations in the human genome, we analyze HPV-capture sequencing
data to identify HPV integration … -scale multi-omics analysis using genomics data from HPV-…
data to identify HPV integration … -scale multi-omics analysis using genomics data from HPV-…
Multi-omics mapping of human papillomavirus integration sites illuminates novel cervical cancer target genes
M Iden, SW Tsaih, YW Huang, P Liu, M Xiao… - British Journal of …, 2021 - nature.com
… details of a multi-omics approach designed to thoroughly annotate HPV integration events
for … Integration analysis from this study revealed multiple integrations in the lncRNA PVT1, a …
for … Integration analysis from this study revealed multiple integrations in the lncRNA PVT1, a …
Multi-omics characterization of productive HPV integration in cervical cancer.
C Sun, J Fan, Y Fu, W Peng, X Li, Y Shen, D Zou, B Xia… - 2022 - ascopubs.org
… We aim to study the characterization of silent and productive HPV integration in cervical …
papillomavirus (HPV), remains a significant public health problem worldwide. HPV integration …
papillomavirus (HPV), remains a significant public health problem worldwide. HPV integration …
Multi-omics data integration reveals metabolome as the top predictor of the cervicovaginal microenvironment
… against HPV at different stages of cervical neoplasia (Fig 1). Using integrated multi-omics, …
Our integrated analysis further highlighted the importance of this key immune mediator, and …
Our integrated analysis further highlighted the importance of this key immune mediator, and …
Unsupervised multi-omics data integration methods: a comprehensive review
N Vahabi, G Michailidis - Frontiers in genetics, 2022 - frontiersin.org
… , including sequential analysis, CCA- and CIA-based, and factor analysis-based … HPV
integration in clade A7-samples. However, the A9-enriched cluster showed partial HPV integration …
integration in clade A7-samples. However, the A9-enriched cluster showed partial HPV integration …
Integrative Multi-Omics Approaches for Identifying Cervical Cancer Therapeutic Targets
SK Duppala, R Yadala, A Velingkar, P Suravajhala… - bioRxiv, 2022 - biorxiv.org
… of HPV integration sites developed using ICC target genes. … Combining metabolomics and
transcriptomic analysis has … This study confirmed combinational analysis of metabolomics …
transcriptomic analysis has … This study confirmed combinational analysis of metabolomics …
Integration of multi-omics data improves prediction of cervicovaginal microenvironment in cervical cancer
… characterized by a dramatic shift in microbiota composition from Lactobacillus to anaerobes,
has been linked to an increased risk of HPV … present an integrated multi-omics analysis of …
has been linked to an increased risk of HPV … present an integrated multi-omics analysis of …
Integrative genomics and transcriptomics analysis reveals potential mechanisms for favorable prognosis of patients with HPV-positive head and neck carcinomas
W Zhang, A Edwards, Z Fang, EK Flemington… - Scientific Reports, 2016 - nature.com
… integrative analysis of clinically-annotated multi-omics HNSCC … TP53 and HPV infection was
rare; (2) Regardless of HPV status… Our analysis further led to some novel observations. They …
rare; (2) Regardless of HPV status… Our analysis further led to some novel observations. They …
Multi-Omics Analysis Showed the Clinical Value of Gene Signatures of C1QC+ and SPP1+ TAMs in Cervical Cancer
… human papillomavirus (HPV) infection, especially HPV intergation (32, 33). On the other
hand, immune system defects play a significant role in cancer progress, It is believed that HPV …
hand, immune system defects play a significant role in cancer progress, It is believed that HPV …
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