[HTML][HTML] Nutritional regulation of insulin secretion: implications for diabetes

P Newsholme, M Krause - The Clinical Biochemist Reviews, 2012 - ncbi.nlm.nih.gov
… stimulus secretion-coupling factors essential for insulin secretion, … It is the mixed nutrient
sensing and stimulus-secretion … ) critical for insulin exocytosis. Briefly, the triggering signal for …

The importance of first‐phase insulin secretion: implications for the therapy of type 2 diabetes mellitus

S Del Prato, A Tiengo - Diabetes/metabolism research and …, 2001 - Wiley Online Library
insulin secretion and action. Insulin resistance is a key feature of type 2 diabetes. However,
… role of the first-phase of insulin secretion in the maintenance of postmeal glucose …

Pharmacological interventions that directly stimulate or modulate insulin secretion from pancreatic β‐cell: implications for the treatment of type 2 diabetes

A Farret, L Lugo‐Garcia, F Galtier… - Fundamental & …, 2005 - Wiley Online Library
… the major stimulus of the pancreatic insulin-secreting β-cells. Glucose … insulin secretory
granules (Figure 1). In addition to this triggering pathway, glucose stimulation of insulin secretion

Insulin secretion and insulin resistance in pregnancy and GDM: implications for diagnosis and management

C Kühl - Diabetes, 1991 - Am Diabetes Assoc
… the nonpregnant state, and the insulin responses to a protein-rich … insulin secretion exist
between pregnant women with normal glucose tolerance (NGT) and women with GDM. Insulin

Hydrogen sulfide in the regulation of insulin secretion and insulin sensitivity: Implications for the pathogenesis and treatment of diabetes mellitus

J Bełtowski, G Wójcicka… - Biochemical pharmacology, 2018 - Elsevier
insulin secretion by increasing intracellular cAMP concentration in β cells [11]. Insulin secretion
is … which innervates pancreatic islets modulates insulin secretion as well. In particular, …

Minireview: implication of mitochondria in insulin secretion and action

A Wiederkehr, CB Wollheim - Endocrinology, 2006 - academic.oup.com
insulin secretion and their utilization in peripheral tissues. … insulin secretion and participate
in the actions of insulin on its … the implication of mitochondria in normal metabolism secretion

Leptin suppression of insulin secretion and gene expression in human pancreatic islets: implications for the development of adipogenic diabetes mellitus

J Seufert, TJ Kieffer, CA Leech, GG Holz… - The Journal of …, 1999 - academic.oup.com
insulin secretion. These findings of a glucose dependence on leptin suppression of insulin
secretion … dependence of leptin suppression of insulin secretion on isolated mouse islets (21). …

Dynamics of insulin secretion and the clinical implications for obesity and diabetes

S Seino, T Shibasaki, K Minami - The Journal of clinical …, 2011 - Am Soc Clin Investig
… The dynamics of insulin secretion can be studied at different levels: the single β … insulin
secretion. This review focuses on our current understanding of the dynamics of insulin secretion

The effect of insulin treatment on insulin secretion and insulin action in type II diabetes mellitus

WT Garvey, JM Olefsky, J Griffin, RF Hamman… - Diabetes, 1985 - Am Diabetes Assoc
insulin secretion was assessed in detail and found to be improved after exogenous insulin
… These studies have clinical implications regarding treatment strategies for type II diabetic …

Pharmacological agents that directly modulate insulin secretion

ME Doyle, JM Egan - Pharmacological reviews, 2003 - ASPET
… Insulinotropic agents may act either by direct stimulation of insulin secretion or by amplifying
insulin secretion induced by other means. Initiators of insulin secretion include glucose and …