Scap is a polytopic membrane protein that functions as a molecular machine to control the
cholesterol content of membranes in mammalian cells. In the 21 years since our laboratory …

Cellular cholesterol homeostasis is maintained by Scap, an endoplasmic reticulum (ER)
protein with eight transmembrane helices. In cholesterol-depleted cells, Scap transports …

Sterol accumulation in membranes blocks the exit of SCAP from the ER, preventing SREBP
cleavage and reducing cholesterol synthesis. Sterols act through SCAP's sterol-sensing …

Sterol regulatory element binding protein (SREBP) cleavage activating protein (SCAP) is a
key regulator of SREBP maturation. SCAP induces translocation of SREBP from the …

SCAP (SREBP cleavage-activating protein) forms a complex with sterol regulatory element-
binding proteins (SREBPs) and escorts them from the endoplasmic reticulum (ER) to the …

Mammalian cells control their membrane composition by regulating the vesicular transport of
membrane-bound sterol regulatory element binding proteins (SREBPs) from endoplasmic …

SREBPs exit the ER in a complex with SCAP. Together, they move to the Golgi where
SREBP is cleaved, releasing a fragment that activates genes encoding lipid biosynthetic …

INTRODUCTION Cholesterol homeostasis is controlled by the sterol regulatory element–
binding protein (SREBP) pathway. SREBPs (SREBP-1a,-1c, and-2) are transcription factors …

Figure 1. Model for the sterol-mediated proteolytic release of SREBPs from membranes.
SCAP functions as a sensor of sterols and a chaperone of SREBPs. When cells are depleted …

The molecular mechanism of how hepatocytes maintain cholesterol homeostasis has
become much more transparent with the discovery of sterol regulatory element binding …