阿尔茨海默病中β 淀粉样蛋白与脑毛细血管内皮细胞的关系

YL Zhang, J Wang, ZN Zhang, Q Su… - 中国神经再生研究(英文版), 2022 - sjzsyj.com.cn
Neurovascular dysfunction, as an integral part of Alzheimer's disease, may have an
important influence on the onset and progression of chronic neurodegenerative processes …

[HTML][HTML] The relationship between amyloid-beta and brain capillary endothelial cells in Alzheimer's disease

YL Zhang, J Wang, ZN Zhang, Q Su… - Neural Regeneration …, 2022 - ncbi.nlm.nih.gov
Neurovascular dysfunction, as an integral part of Alzheimer's disease, may have an
important influence on the onset and progression of chronic neurodegenerative processes …

Vascular Transport of Alzheimer's Amyloid β Peptides and Apolipoproteins

BV Zlokovic, J Ghiso, B Frangione - Cerebral Amyloid Angiopathy in …, 2000 - Springer
Deposition of amyloid β (Aβ) in the central nervous system (CNS) occurs during normal
aging and is accelerated by Alzheimer's disease. Aβ accumulation in the CNS is considered …

[HTML][HTML] β 淀粉样蛋白跨血脑屏障转运机制研究进展

张海静, 赵春晖, 张文生 - 2016 - html.rhhz.net
β 淀粉样蛋白(amyloid beta-peptides, Aβ) 是阿尔茨海默病(Alzheimer's disease, AD)
的主要病理特征. Aβ 在患者脑内的积聚由多种因素诱导, 其中血脑屏障(blood-brain barrier …

Distinct uptake kinetics of Alzheimer disease amyloid-β 40 and 42 at the blood-brain barrier endothelium

N Sharda, KM Ahlschwede, GL Curran, VJ Lowe… - … of Pharmacology and …, 2021 - ASPET
Blood-brain barrier (BBB) endothelial cells lining the cerebral microvasculature maintain
dynamic equilibrium between soluble amyloid-β (A β) levels in the brain and plasma. The …

Deposition and clearance of β-amyloid in the brain

K Wakabayashi, Y Miki - Brain and Nerve= Shinkei Kenkyu no …, 2013 - europepmc.org
Amyloid β-protein (Aβ) is deposited as senile plaques and vascular amyloid in the brain of
patients with Alzheimer's disease as well as in a significant proportion of non-demented …

Blood-Brain Barrier Transport of Circulating Alzheimer′ s Amyloid β

BV Zlokovic, J Ghiso, JB Mackic, JG McComb… - Biochemical and …, 1993 - Elsevier
The origin of amyloid β (Aβ) deposited in brain and cerebral blood vessels of patients with
Alzheimer′ s Disease (AD) is not known. In this study, we tested whether soluble Aβ (sAβ) …

Aβ42 production in brain capillary endothelial cells after oxygen and glucose deprivation

A Bulbarelli, E Lonati, A Brambilla, A Orlando… - Molecular and Cellular …, 2012 - Elsevier
Although the diverse triggers of AD are still under debate, the hypothesis of the contribution
of cerebrovascular deficiencies has emerged in recent years. Cerebrovascular dysfunction …

Modulation of Amyloid-β 1–40 Transport by ApoA1 and ApoJ Across an in vitro Model of the Blood-Brain Barrier

C Merino-Zamorano… - Journal of …, 2016 - content.iospress.com
Amyloid-β (Aβ) accumulation in Alzheimer's disease (AD) and cerebral amyloid angiopathy
(CAA) is likely caused by the impairment of its brain clearance that partly occurs through the …

[HTML][HTML] Mixed oligomers and monomeric amyloid-β disrupts endothelial cells integrity and reduces monomeric amyloid-β transport across hCMEC/D3 cell line as an …

H Qosa, H LeVine III, JN Keller, A Kaddoumi - Biochimica et Biophysica …, 2014 - Elsevier
Senile amyloid plaques are one of the diagnostic hallmarks of Alzheimer's disease (AD).
However, the severity of clinical symptoms of AD is weakly correlated with the plaque load …