Characterization of differentially methylated regions in 3 bovine imprinted genes: a model for studying human germ-cell and embryo development

T Hansmann, J Heinzmann, C Wrenzycki… - … and Genome Research, 2011 - karger.com
Correct imprinting is crucial for normal fetal and placental development in mammals.
Experimental evidence in animal models and epidemiological studies in humans suggest …

[HTML][HTML] DNA methylation in the IGF2 intragenic DMR is re-established in a sex-specific manner in bovine blastocysts after somatic cloning

C Gebert, C Wrenzycki, D Herrmann, D Gröger, J Thiel… - Genomics, 2009 - Elsevier
The recent identification of an intragenic differentially methylated region (DMR) within the
last exon of the bovine Insulin-like growth factor 2 (IGF2) gene provides a diagnostic tool for …

Characterization of the methylation status of five imprinted genes in sheep gametes

A Colosimo, G Di Rocco, V Curini, V Russo… - Animal …, 2009 - Wiley Online Library
Genomic imprinting is a mammalian developmental process that uses epigenetic
mechanisms to induce monoallelic and parental‐specific expression of particular autosomal …

Methylation status of putative differentially methylated regions of porcine IGF2 and H19

DW Han, YB Im, JT Do, MK Gupta… - Molecular …, 2008 - Wiley Online Library
This study was designed to identify the putative differentially methylated regions (DMRs) of
the porcine imprinted genes insulin‐like growth factor 2 and H19 (IGF2‐H19), and to assess …

Methylation dynamics of imprinted genes in mouse germ cells

D Lucifero, C Mertineit, HJ Clarke, TH Bestor… - Genomics, 2002 - Elsevier
DNA methylation differences between maternal and paternal alleles of many imprinted
genes are inherited from the male and female gametes and subsequently maintained during …

mRNA Levels of Imprinted Genes in Bovine In Vivo Oocytes, Embryos and Cross Species Comparisons with Humans, Mice and Pigs

Z Jiang, H Dong, X Zheng, SL Marjani, DM Donovan… - Scientific Reports, 2015 - nature.com
Twenty-six imprinted genes were quantified in bovine in vivo produced oocytes and
embryos using RNA-seq. Eighteen were detectable and their transcriptional patterns were …

DNA methylation changes during preimplantation development reveal inter-species differences and reprogramming events at imprinted genes

E Ivanova, S Canovas, S Garcia-Martínez, R Romar… - Clinical …, 2020 - Springer
Preimplantation embryos experience profound resetting of epigenetic information inherited
from the gametes. Genome-wide analysis at single-base resolution has shown similarities …

[HTML][HTML] The bovine IGF2 gene is differentially methylated in oocyte and sperm DNA

C Gebert, C Wrenzycki, D Herrmann, D Gröger… - Genomics, 2006 - Elsevier
The insulin-like growth factor 2 gene (IGF2) encodes an essential growth factor and is
imprinted in various mammalian species. Differentially methylated regions (DMRs) are often …

Epigenetic profile of developmentally important genes in bovine oocytes

J Heinzmann, T Hansmann, D Herrmann… - Molecular …, 2011 - Wiley Online Library
Assisted reproductive technologies are associated with an increased incidence of
epigenetic aberrations, specifically in imprinted genes. Here, we used the bovine oocyte as …

Is ART changing the epigenetic landscape of imprinting?

W Mak, JR Weaver… - Animal Reproduction …, 2018 - animal-reproduction.org
Imprinted genes, which are epigenetically modified such that only a single parental allele is
expressed, are often regulated by imprinting control regions (ICRs). ICRs typically are DNA …