替勃龙调节老年雄性小鼠海马神经元可塑性: 可能的作用途径
T Neri-Gómez, J Espinosa-Raya… - 中国神经再生研究 …, 2017 - sjzsyj.com.cn
神经原纤维缠结是阿尔茨海默病患者大脑的特征性病理改变, 是Tau 蛋白发生过度磷酸化所致.
性激素替代治疗可以减少神经元纤维缠结, 但有致瘤的风险. 合成激素替勃龙因副作用相对较小 …
性激素替代治疗可以减少神经元纤维缠结, 但有致瘤的风险. 合成激素替勃龙因副作用相对较小 …
[HTML][HTML] Tibolone modulates neuronal plasticity through regulating Tau, GSK3β/Akt/PI3K pathway and CDK5 p35/p25 complexes in the hippocampus of aged male …
T Neri-Gómez, J Espinosa-Raya… - Neural Regeneration …, 2017 - journals.lww.com
Aging is a key risk factor for cognitive decline and age-related neurodegenerative disorders.
Also, an age-related decrease in sex steroid hormones may have a negative impact on the …
Also, an age-related decrease in sex steroid hormones may have a negative impact on the …
Androgens regulate tau phosphorylation through PI3K-Akt-GSK3β signaling.
M Yao, ER Rosario, CJ Pike - Neuroscience, 2022 - europepmc.org
Age-related testosterone depletion in men is a risk factor for Alzheimer's disease (AD). How
testosterone modulates AD risk remains to be fully elucidated, although regulation of tau …
testosterone modulates AD risk remains to be fully elucidated, although regulation of tau …
山茱萸环烯醚萜苷抑制GSK-3β 活性拮抗tau 蛋白过度磷酸化机制
李雪莲， 杨翠翠， 张兰， 石京山 - 神经药理学报, 2017 - ssw-l.com
目的: 观察山茱萸环烯醚萜苷(cornel iridoid glycoside, CIG) 对糖原合成酶激酶-3β (glycogen
synthase kinase-3β, GSK-3β) 活性的影响, 及其对阿尔茨海默病(Alzheimer's disease, AD) …
synthase kinase-3β, GSK-3β) 活性的影响, 及其对阿尔茨海默病(Alzheimer's disease, AD) …
Androgens regulate tau phosphorylation through phosphatidylinositol 3-kinase–protein kinase B–glycogen synthase kinase 3β signaling
M Yao, ER Rosario, JC Soper, CJ Pike - Neuroscience, 2022 - Elsevier
Age-related testosterone depletion in men is a risk factor for Alzheimer's disease (AD). How
testosterone modulates AD risk remains to be fully elucidated, although regulation of tau …
testosterone modulates AD risk remains to be fully elucidated, although regulation of tau …