The biological properties of cetuximab

B Vincenzi, G Schiavon, M Silletta, D Santini… - Critical reviews in …, 2008 - Elsevier
Cetuximab is a recombinant chimeric human murine immunoglobulin G1 antibody that binds
to the extra-cellular domain of epidermal growth factor receptor with a higher affinity than …

Cetuximab: a review of its use in squamous cell carcinoma of the head and neck and metastatic colorectal cancer

SKA Blick, LJ Scott - Drugs, 2007 - Springer
Cetuximab (Erbitux®) is a human-mouse chimeric monoclonal antibody, which competitively
binds to the accessible extracellular domain of the epidermal growth factor receptor (EGFR) …

Cetuximab: an epidermal growth factor receptor monoclonal antibody for the treatment of colorectal cancer

SF Wong - Clinical therapeutics, 2005 - Elsevier
BACKGROUND:: Cetuximab is a recombinant human/mouse chimeric epidermal growth
factor receptor (EGFR) monoclonal antibody. It was approved by the US Food and Drug …

[PDF][PDF] Cetuximab: from bench to bedside

B Vincenzi, A Zoccoli, F Pantano… - Current cancer drug …, 2010 - researchgate.net
Cetuximab (IMC-C225, Erbitux ImClone Systems Inc, New York, NY) is a recombinant,
human/mouse chimeric monoclonal antibody (MAb) that binds specifically to the …

Cetuximab: an epidermal growth factor receptor chemeric human-murine monoclonal antibody.

J Harding, B Burtness - Drugs of today (Barcelona, Spain: 1998), 2005 - europepmc.org
The epidermal growth factor receptor (EGFR) is a member of the ErbB family of receptors. It
is composed of extracellular domains, including a ligand-binding domain, a hydrophobic …

Cetuximab and the head and neck squamous cell cancer

R Concu, M Cordeiro - Current topics in medicinal chemistry, 2018 - ingentaconnect.com
The Head and Neck Squamous Cell Cancer (HNSCC) is the most common type of head and
neck cancer (more than 90%), and all over the world more than a half million people have …

The EGFR as a target for anticancer therapy—focus on cetuximab

J Baselga - European journal of cancer, 2001 - Elsevier
The anti-epidermal-growth-factor-receptor (EGFR) monoclonal antibody cetuximab
specifically binds to the EGFR with high affinity, blocking growth-factor binding, receptor …

Review of cetuximab in the treatment of squamous cell carcinoma of the head and neck

M Merlano, M Occelli - Therapeutics and clinical risk management, 2007 - Taylor & Francis
Cetuximab is a monoclonal antibody able to inhibit and to degrade the transmembrane
receptor Her-1, also known as epidermal growth factor receptor (EGFR). The inhibition of …

Antibody‐dependent cellular cytotoxicity of cetuximab against tumor cells with wild‐type or mutant epidermal growth factor receptor

H Kimura, K Sakai, T Arao, T Shimoyama… - Cancer …, 2007 - Wiley Online Library
Cetuximab (Erbitux, IMC‐C225) is a monoclonal antibody targeted to the epidermal growth
factor receptor (EGFR). To clarify the mode of antitumor action of cetuximab, we examined …

Cetuximab in the treatment of head and neck cancer

J Bernier - Expert review of anticancer therapy, 2006 - Taylor & Francis
Approaches to the treatment of locally advanced and recurrent and/or metastatic squamous
cell carcinoma of the head and neck (SCCHN) have been limited by their toxicity. Effective …