Abstract p7 蛋白是一个介于丙型肝炎病毒(HCV) 结构蛋白和非结构蛋白之间的一小蛋白,
在脂质膜中形成六聚体阳离子通道, 在病毒的自然感染过程中起一定的作用 …

The p7 membrane polypeptide from HCV is essential for virus infection. It exhibits ion-
channel activity reported to be specifically blocked by various compounds. These properties …

Abstract p7, a 63‐residue peptide encoded by hepatitis C virus (HCV), a major pathogen
associated with a risk of developing severe liver disease, is involved in ion channel activity …

Hepatitis C virus (HCV) is a major global health burden with 2–3% of the world׳ s population
being chronically infected. Persistent infection can lead to cirrhosis and hepatocellular …

We have identified the membrane-active regions of the hepatitis C virus p7 protein by
performing an exhaustive study of membrane rupture, hemifusion, and fusion induced by a …

The p7 protein from the hepatitis C virus (HCV) is a 63 amino acid long polypeptide that is
essential for replication, and is involved in protein trafficking and proton transport. Therefore …

The hepatitis C virus (HCV) p7 protein is critical for virus production and an attractive
antiviral target. p7 is an ion channel when reconstituted in artificial lipid bilayers, but channel …

The role of the hepatitis C virus (HCV) p7 protein in the virus life cycle is not known. Previous
in vitro data indicated that this 63-aa polypeptide is located in the endoplasmic reticulum …

The small membrane protein p7 of hepatitis C virus forms oligomers and exhibits ion
channel activity essential for virus infectivity. These viroporin features render p7 an attractive …

Hepatitis C virus (HCV) cannot be grown in vitro, making biochemical identification of new
drug targets especially important. HCV p7 is a small hydrophobic protein of unknown …