Concurrent delivery of tumor antigens and activation signals to dendritic cells by irradiated CD40 ligand-transfected tumor cells resulted in efficient activation of …
KJ Liu, LF Lu, HT Cheng, YM Hung, SR Shiou… - Cancer Gene …, 2004 - nature.com
To improve the efficacy of tumor cell-based and dendritic cell (DC)-based cancer vaccines,
this study explored the potential of a new cancer vaccine strategy, that is, the use of CD40 …
this study explored the potential of a new cancer vaccine strategy, that is, the use of CD40 …
Functional maturation of dendritic cells by exposure to CD40L transgenic tumor cells, fibroblasts or keratinocytes
T Felzmann, M Buchberger, M Lehner, D Printz… - Cancer letters, 2001 - Elsevier
Tumor antigen pulsed dendritic cells (DCs) can induce anti-tumor immunity. We studied
strategies for the reliable generation of such a tumor vaccine by functional maturation of DCs …
strategies for the reliable generation of such a tumor vaccine by functional maturation of DCs …
Dendritic cells modified to express CD40 ligand elicit therapeutic immunity against preexisting murine tumors
T Kikuchi, MAS Moore… - Blood, The Journal of the …, 2000 - ashpublications.org
Abstract CD40 ligand (CD40L) is essential for the initiation of antigen-specific T-cell
responses. This study is based on the hypothesis that dendritic cells (DCs) genetically …
responses. This study is based on the hypothesis that dendritic cells (DCs) genetically …
Adenovirus-mediated CD40 ligand gene-engineered dendritic cells elicit enhanced CD8+ cytotoxic T-cell activation and antitumor immunity
Y Liu, X Zhang, W Zhang, Z Chen, T Chan, K Ali… - Cancer gene …, 2002 - nature.com
CD40L, the ligand for CD40 on dendritic cells (DCs), plays an important role in their
activation and is essential for induction of antigen-specific T-cell responses. In the present …
activation and is essential for induction of antigen-specific T-cell responses. In the present …
Enhanced protective immunity derived from dendritic cells with phagocytosis of CD40 ligand transgene-engineered apoptotic tumor cells via increased dendritic cell …
S Parameswaran, M Khalil, KA Ahmed… - Tumori …, 2015 - journals.sagepub.com
Aims and Background Dendritic cells (DCs) play a pivotal role in regulating CD8+ cytotoxic T-
lymphocyte (CTL) responses. Currently, DC vaccines have been used in experimental …
lymphocyte (CTL) responses. Currently, DC vaccines have been used in experimental …
In Vivo Antitumor Effect of CD40L-transduced Tumor Cells as a Vaccine for B-Cell Lymphoma
J Briones, J Timmerman, R Levy - Cancer research, 2002 - AACR
Abstract CD40-CD40 ligand (CD40L) interactions play a critical role in the activationof
cellular immunity. CD40L enhances the antigen presentation function of CD40-expressing B …
cellular immunity. CD40L enhances the antigen presentation function of CD40-expressing B …
Combination of monocyte-derived dendritic cells and activated T cells which express CD40 ligand: a new approach to cancer immunotherapy
T Sato, M Terai, R Yasuda, R Watanabe, D Berd… - Cancer Immunology …, 2004 - Springer
Interactions between dendritic cells (DCs) and activated T cells are critically important for the
establishment of an effective immune response. To develop the basis for a new DC-based …
establishment of an effective immune response. To develop the basis for a new DC-based …
Linkage of CD40L to a self-tumor antigen enhances the antitumor immune responses of dendritic cell-based treatment
CD40–CD40 ligand (CD40L) interaction is an important costimulatory signal in the
interaction between T cells and antigen-presenting cells (APC). In the present study, we …
interaction between T cells and antigen-presenting cells (APC). In the present study, we …
Tumor regression induced by intratumor administration of adenovirus vector expressing CD40 ligand and naive dendritic cells
T Kikuchi, N Miyazawa, MAS Moore, RG Crystal - Cancer research, 2000 - AACR
We have previously shown that in vivo genetic modification of tumors with an adenovirus
(Ad) vector engineered to express CD40 ligand (AdmCD40L) induces tumor-specific CTLs …
(Ad) vector engineered to express CD40 ligand (AdmCD40L) induces tumor-specific CTLs …
Dendritic and tumor cell fusions transduced with adenovirus encoding CD40L eradicate B-cell lymphoma and induce a Th17-type response
Fusion of dendritic cells and tumor cells (FCs) constitutes a promising tool for generating an
antitumor response because of their capacity to present tumor antigens and provide …
antitumor response because of their capacity to present tumor antigens and provide …