Interactions between CD40 and its ligand, CD154 (CD40L, gp39), have been shown to play
a central role in the regulation of humoral immunity. Recent evidence suggests that this …

Ligation of CD40 induces maturation of dendritic cells (DC) and could be a useful target for
vaccines. In this study, we have constructed two types of Ab-based vaccine constructs that …

Targeted delivery of tumor antigen genes to dendritic cells (DCs) using adenoviral (Ad)
vectors holds great potential for cancer immunotherapy. We previously showed that CD40 …

Genetic immunization through ex vivo transduction of dendritic cells has been suggested as
an effective approach to enhance antitumor immunity by activating both CD4+ and CD8+ T …

In situ delivery of tumor-associated antigen (TAA) genes into dendritic cells (DC) has great
potential as a generally applicable tumor vaccination approach. Although adenoviruses (Ad) …

Previous work has established a role for CD40-mediated signals in eliciting helper-
dependent CD8+ T cell responses. Here we investigated the effects of in vivo CD40 …

Background Pancreatic ductal adenocarcinoma (PDAC) is notoriously resistant to treatment
including checkpoint-blockade immunotherapy. We hypothesized that a bimodal treatment …

Cell-based vaccination strategies to induce functional tumor-specific T cells in cancer
patients have focused on using autologous dendritic cells. An alternative approach is to use …

In cancer, the coordinate engagement of professional APC and Ag-specific cell-mediated
effector cells may be vital for the induction of effective antitumor responses. We speculated …

Targeting antigens to antigen presenting cells (APC) enhances the potency of recombinant
protein CD8+ T cell vaccines. Recent comparisons of recombinant protein-based dendritic …