Heat shock protein-based vaccines have been shown to immunize against cancer and
infectious diseases in both prophylactic and therapeutic protocols. So far, four classes of …

Heat shock protein gp96 primes class I restricted cytotoxic T cells against antigens present
in the cells from which it was isolated. Moreover, gp96 derived from certain tumors functions …

Japanese encephalitis virus (JEV), a mosquito-borne flavivirus, is an important human
pathogen. Mouse brain-derived, inactivated JEV vaccines have contributed greatly to the …

Many tumor immunotherapy efforts are focused on the generation of strong T‐cell response
against tumor antigens. However, strong T‐cell response does not always coincide with …

Heat shock proteins (HSP) induce antitumor‐specific immunity via a unique mechanism, but
HSP alone fails to produce a satisfactory antitumor efficacy. We considered that the potent …

Abstract Heat shock protein 105 (HSP105) is overexpressed in many cancers, including
colorectal cancer (CRC) and esophageal cancer (EC). We carried out a phase I clinical trial …

Japanese encephalitis (JE) poses a serious threat to the world's public health yet without a
cure, the only way to prevent Japanese encephalitis virus (JEV) infection is vaccination. Live …

Recently, we reported that heat shock protein 105 (HSP105) DNA vaccination induced anti-
tumor immunity. In this study, we set up a preclinical study to investigate the usefulness of …

BACKGROUND AND OBJECTIVES: Pathogen-derived molecules are danger signals and
are able to activate innate immunity that in turn controls and regulates generation of …

Vaccination against tumors relies on tumor-associated antigens, and has been quite
successful with synthetic peptides used as immunogens. Gp100 is a human melanoma …