Glucocorticoid sensitivity is highly variable in critically ill patients with septic shock and is associated with disease severity
Objectives: To measure tissue glucocorticoid sensitivity in patients with septic shock and
determine its relationship to standard measurements of adrenal function and of outcome …
determine its relationship to standard measurements of adrenal function and of outcome …
Septic serum induces glucocorticoid resistance and modifies the expression of glucocorticoid isoforms receptors: a prospective cohort study and in vitro experimental …
J Guerrero, HA Gatica, M Rodríguez, R Estay… - Critical Care, 2013 - Springer
Background A protective role for glucocorticoid therapy in animal models of sepsis was
shown many decades ago. In human sepsis, there is new interest in glucocorticoid therapy …
shown many decades ago. In human sepsis, there is new interest in glucocorticoid therapy …
Adrenal axis function does not appear to be associated with hemodynamic improvement in septic shock patients systematically receiving glucocorticoid therapy
J Morel, C Venet, Y Donati, D Charier, J Liotier… - Intensive care …, 2006 - Springer
Objective There is mounting evidence showing the value of low-dose corticosteroids in
patients with septic shock requiring vasopressor therapy. It remains unclear whether adrenal …
patients with septic shock requiring vasopressor therapy. It remains unclear whether adrenal …
Clinical review: corticotherapy in sepsis
H Prigent, V Maxime, D Annane - Critical Care, 2003 - Springer
The use of glucocorticoids (corticotherapy) in severe sepsis is one of the main controversial
issues in critical care medicine. These agents were commonly used to treat sepsis until the …
issues in critical care medicine. These agents were commonly used to treat sepsis until the …
Relative adrenal insufficiency as a predictor of disease severity, mortality, and beneficial effects of corticosteroid treatment in septic shock
MFC De Jong, A Beishuizen, JJ Spijkstra… - Critical care …, 2007 - journals.lww.com
Objective: To evaluate the concept of relative adrenal insufficiency necessitating
corticosteroid therapy in septic shock. Design: Retrospective study. Setting: Medical-surgical …
corticosteroid therapy in septic shock. Design: Retrospective study. Setting: Medical-surgical …
Glucocorticoid insufficiency in patients who present to the hospital with severe sepsis: a prospective clinical trial
S Manglik, E Flores, L Lubarsky, F Fernandez… - Critical care …, 2003 - journals.lww.com
Glucocorticoid insufficiency in patients who present to the... : Critical Care Medicine
Glucocorticoid insufficiency in patients who present to the hospital with severe sepsis: A …
Glucocorticoid insufficiency in patients who present to the hospital with severe sepsis: A …
Assessment of tissue cortisol activity
J Cohen, B Venkatesh - Critical Care and Resuscitation, 2009 - Elsevier
The concept of relative adrenal insufficiency in patients with severe sepsis continues to be
controversial. This arises in part from the lack of an accepted “gold standard” for the …
controversial. This arises in part from the lack of an accepted “gold standard” for the …
[HTML][HTML] Adrenal insufficiency in sepsis
BACKGROUND AND OBJECTIVES: Corticosteroids were introduced in the treatment of
severe infection as early as in the nineteen forties. Several" negative" randomized controlled …
severe infection as early as in the nineteen forties. Several" negative" randomized controlled …
Relative adrenal insufficiency in patients with septic shock: comparison of low-dose and conventional corticotropin tests
V Siraux, D De Backer, G Yalavatti, C Mélot… - Critical care …, 2005 - journals.lww.com
Objective: To compare a low-dose (1 μg) corticotropin stimulation test with the more
standard (250 μg) test for the diagnosis of relative adrenal insufficiency. Design: Diagnostic …
standard (250 μg) test for the diagnosis of relative adrenal insufficiency. Design: Diagnostic …
Adrenal function in sepsis: the retrospective Corticus cohort study
D Lipiner-Friedman, CL Sprung, PF Laterre… - Critical care …, 2007 - journals.lww.com
Objective: To refine the value of baseline and adrenocorticotropin hormone (ACTH)-
stimulated cortisol levels in relation to mortality from severe sepsis or septic shock. Design …
stimulated cortisol levels in relation to mortality from severe sepsis or septic shock. Design …