OBJECTIVE.: Vaccination based on tumor antigen is an attractive strategy for cancer
prevention and therapy. Cervical cancer is highly associated with human papillomavirus …

Objective: DNA vaccines encoding the HPV16 E7 and E6 oncoproteins epitope genetically
fused to the HSP70 N fragments were tested in mice for induction of T cell-mediated …

In this study, we explored the protective anti-tumor potency of mouse (self) Hsp70 or Hsp110-
based DNA vaccination approach targeting a tumor-associated antigen, human papilloma …

Background: Vaccines capable of controlling tumor virus based infections are found difficult
to develop due to the consistence latent infection in the host. DNA vaccines are attractive …

Human papillomavirus, particularly type 16 (HPV16) is present in more than 99% of cervical
cancers. E7 is the major oncogenic protein produced in cervical cancer-associated HPV16 …

Nucleic acid vaccines represent an attractive approach to generating antigen-specific
immunity because of their stability and simplicity of delivery. However, there is still a need to …

Using human papillomavirus type 16 (HPV16) E7 as an antigen and Heat Shock Protein 70
as adjuvant, we constructed a DNA vaccine by linking HSP70 gene to E7 C91G/gene. Mice …

ABSTRACT A variety of heat shock protein 70 (HSP70)-associated therapeutic vaccines
including protein vaccine, peptide vaccine, tumor cell vaccine and DNA vaccine, have been …

Millions of women are currently infected with high-risk human papillomavirus (HPV), which is
considered to be a major risk factor for cervical cancer. Thus, it is urgent to develop …

DNA vaccines have emerged as an attractive approach for antigen-specific cancer
immunotherapy. We have previously linked Mycobacterium tuberculosis heat shock protein …