Aliskiren 在心血管及腎臟保護扮演的角色

陳秋如, 項怡平, 李炳鈺, 鄭奕帝, 李建德 - 臺灣臨床藥學雜誌, 2012 - airitilibrary.com
腎素-血管昇壓素-醛固酮系統(renin-angiotensin-aldosterone system, RAAS) 是心血管,
腎臟及腎上腺皮質功能之重要調節系統; 而過度活化與心血管及腎臟疾病有直接的關連性 …

新型高血壓治療藥-腎素抑制劑(Renin Inhibitors)

吳孟修, 鄭景仁, 王志鴻, 林繼謨 - 內科學誌, 2008 - airitilibrary.com
腎素-血管昇壓素系統(rennin-angiotensin system, RAS) 對於調節血壓, 平衡電解質濃度,
血管生長等扮演著很重要的角色. 藉由血管昇壓素轉換酵素抑制劑(angiotensin converting …

Effects of angiotensin-converting enzyme inhibitors and angiotensin II receptor blockers on accumulation of aliskiren in the kidney

A Rahman, K Ohmori, M Kohno… - Journal of …, 2013 - journals.lww.com
Increased activity of the renin–angiotensin–aldosterone system (RAAS) plays an important
role in the pathogenesis of chronic kidney disease (CKD)[1, 2]. Inhibition of the RAAS with …

[HTML][HTML] Direct Renin inhibitor: aliskiren in chronic kidney disease

Y Morishita, E Kusano - Nephro-urology monthly, 2013 - ncbi.nlm.nih.gov
The renin-angiotensin-aldosterone system (RAAS) plays pivotal roles in the pathogenesis of
chronic kidney disease (CKD) progression and its increased complications such as …

[PDF][PDF] Aliskiren-an antihypertensive renin inhibitor in the treatment of patients with chronic kidney disease

K Łukawski… - Journal of Pre-Clinical and …, 2017 - bibliotekanauki.pl
Introduction. The renin-angiotensin-aldosterone system (RAAS) plays an important role in
the pathogenesis of hypertension, cardiovascular diseases (CVDs) and chronic kidney …

Efficacy and safety profile of aliskiren: practical implications for clinicians

F Angeli, G Reboldi, C Poltronieri, E Angeli… - Current drug …, 2014 - ingentaconnect.com
Renin-angiotensin-system (RAS) is an enzymatic cascade that plays a pivotal role in the
development of arterial hypertension, kidney disease and cardiovascular disease. Inhibition …

Role of aliskiren in cardio-renal protection and use in hypertensives with multiple risk factors

E Pimenta, S Oparil - Vascular Health and Risk Management, 2009 - Taylor & Francis
The renin-angiotensin-aldosterone system (RAAS) is an important mediator of blood
pressure (BP) and volume regulation in both normotensive and hypertensive persons and is …

Aliskiren in the treatment of hypertension and organ damage

G Riccioni - Cardiovascular therapeutics, 2011 - Wiley Online Library
Hypertension is one of the most important risk factor and cause of cardiovascular diseases
(CVD). Chronic activation of the renin–angiotensin–aldosterone system (RAAS) plays a key …

Aliskiren as a novel therapeutic agent for hypertension and cardio-renal diseases

A Rashikh, SJ Ahmad, KK Pillai… - Journal of Pharmacy …, 2012 - academic.oup.com
Objectives High blood pressure (BP) is a major risk factor for cardiovascular and renal
complications. A majority of treated hypertensive patients still complain of high BP. The renin …

[HTML][HTML] Aliskiren: a novel renoprotective agent or simply an alternative to ACE inhibitors?

KJ Wiggins, DJ Kelly - Kidney international, 2009 - Elsevier
Chronic kidney disease (CKD) is a common condition that is increasing in prevalence in
developed nations. The economic and psychosocial costs of CKD are considerable, and are …