Globo H 於犬惡性乳腺腫瘤之預後價值的評估與探討
郭君婷 - 2019 - tdr.lib.ntu.edu.tw
Globo H 為一常見分布於癌細胞表面的醣類抗原, 它在正常細胞的表現受限,
因此可以做為辨識惡性細胞的標籤, 並適合成為癌症免疫治療的標靶. Globo H …
因此可以做為辨識惡性細胞的標籤, 並適合成為癌症免疫治療的標靶. Globo H …
[HTML][HTML] Investigation of the impact of Globo-H expression on the progression of gastric cancer
HT Hsu, TM Kuo, CY Wei, JY Huang… - American Journal of …, 2023 - ncbi.nlm.nih.gov
Abstract Globo-H (GH), a globo-series glycosphingolipid antigen that is synthesized by key
enzymes β1, 3-galactosyltransferase V (β3GalT5), fucosyltransferase (FUT) 1 and 2, is …
enzymes β1, 3-galactosyltransferase V (β3GalT5), fucosyltransferase (FUT) 1 and 2, is …
[HTML][HTML] The clinical relevance of humoral immune responses to Globo H-KLH vaccine adagloxad simolenin (OBI-822)/OBI-821 and expression of Globo H in …
JT Hung, IJ Chen, SH Ueng, CS Huang… - … for immunotherapy of …, 2022 - ncbi.nlm.nih.gov
An international randomized phase II trial of Globo H (GH) vaccine, adagloxad
simolenin/OBI-821 in 349 patients with metastatic breast cancer showed longer progression …
simolenin/OBI-821 in 349 patients with metastatic breast cancer showed longer progression …
Abstract P5-08-01: Globo H: A Globo series glycosphingolipid target antigen in breast cancer
DS Sigal, AM Tsimberidou, IJ Chen, P Hsu, T Pearce - Cancer Research, 2022 - AACR
Cancer cells may be differentiated from normal cells by the surface expression of unusual
glycosylation patterns: tumor-associated carbohydrate antigens (TACAs) may be expressed …
glycosylation patterns: tumor-associated carbohydrate antigens (TACAs) may be expressed …
[PDF][PDF] Investigation of the impact of Globo-H expression on the progression of gastric cancer
CTC Lai - e-century.us
Globo-H (GH), a globo-series glycosphingolipid antigen that is synthesized by key enzymes
β1, 3-galactosyltransferase V (β3GalT5), fucosyltransferase (FUT) 1 and 2, is highly …
β1, 3-galactosyltransferase V (β3GalT5), fucosyltransferase (FUT) 1 and 2, is highly …
[PDF][PDF] Globo H-targeted CAR T cell cancer immunotherapy
JS Lai, SL Jian, WE Chan, MT Lai - Cancer Res, 2023 - s3.ap-northeast-1.amazonaws.com
BACKGROUND• Globo H (GH), a Globo-series glycosphingolipid (GSL), is highly expressed
in epithelial tumors, such as colon, endometrial, gastric, pancreatic, lung, prostate, and …
in epithelial tumors, such as colon, endometrial, gastric, pancreatic, lung, prostate, and …
Randomized phase II/III trial of active immunotherapy with OPT-822/OPT-821 in patients with metastatic breast cancer.
1003 Background: Globo H is a glycolipid that is highly expressed in breast cancer (BC).
Active immunotherapy with OPT-822, a Globo H–KLH conjugate, and the adjuvant OPT-821 …
Active immunotherapy with OPT-822, a Globo H–KLH conjugate, and the adjuvant OPT-821 …
Anti-tumor efficacy and potential mechanism of action of a novel therapeutic humanized anti-Globo H antibody, OBI-888
YC Chen, MC Yang, YC Tsai, HW Chang, CL Hsieh… - Cancer Research, 2019 - AACR
Abstract Background: Globo H (GH) is a hexasaccharide expressed on various cancer types.
We therefore designed OBI-888, a humanized monoclonal IgG1 antibody targeting GH, as a …
We therefore designed OBI-888, a humanized monoclonal IgG1 antibody targeting GH, as a …
[PDF][PDF] Globo H expression in metastatic colorectal cancer (CRC)
P Jayachandran, Y Baca, J Xiu, J Zhang… - J. Clin …, 2021 - carislifesciences.com
• Globo H is a carbohydrate antigen that is highly expressed on the cell surface of epithelial
cancers but not in normal tissue, and has been reported to correlate with poor prognosis.• …
cancers but not in normal tissue, and has been reported to correlate with poor prognosis.• …
The role of Globo H in cancer cell survival
TM Kuo, YC Tsai, CC Lee, JS Lai - Cancer Research, 2020 - AACR
Abstract BACKGROUND: Globo H (GH), a glycosphingolipid (GSL) carbohydrate antigen, is
found on a variety of epithelial tumors and is a promising target for cancer immunotherapy …
found on a variety of epithelial tumors and is a promising target for cancer immunotherapy …