Development of a novel Hsp70-based DNA vaccine as a multifunctional antigen delivery system

A Yamaoka, X Guan, S Takemoto, M Nishikawa… - Journal of controlled …, 2010 - Elsevier
DNA vaccination is a simple and effective method to induce immune responses against a
variety of tumors as well as infectious diseases. Vaccination with major histocompatibility …

Generation of anti-tumor immunity using mammalian heat shock protein 70 DNA vaccines for cancer immunotherapy

Y Li, J Subjeck, G Yang, E Repasky, XY Wang - Vaccine, 2006 - Elsevier
In this study, we explored the protective anti-tumor potency of mouse (self) Hsp70 or Hsp110-
based DNA vaccination approach targeting a tumor-associated antigen, human papilloma …

Heat shock protein derivatives for delivery of antigens to antigen presenting cells

M Nishikawa, S Takemoto, Y Takakura - International journal of …, 2008 - Elsevier
Delivery of antigens to antigen presenting cells (APCs) is a key issue for developing
effective cancer vaccines. Controlling the tissue distribution of antigens can increase antigen …

Enhanced generation of cytotoxic T lymphocytes by increased cytosolic delivery of MHC class I epitope fused to mouse heat shock protein 70 via polyhistidine …

S Takemoto, M Nishikawa, T Otsuki, A Yamaoka… - Journal of controlled …, 2009 - Elsevier
Heat shock protein 70 (Hsp70)-associated antigens in a soluble form have been shown to
elicit strong antigen-specific cytotoxic T lymphocyte (CTL) responses following immunization …

The preparation of HL-60 cells vaccine expressing BCG heat shock protein 70 and detection of its immunogenicity in vitro

XL Li, YX Zhao, LR Sun, J Yang… - Human Vaccines & …, 2012 - Taylor & Francis
Gene-modified cell vaccines are the best way to achieve the immunotherapy for all types of
acute leukemia. In this study, the recombinant eukaryotic expression vector (pDisplay …

Secretory heat-shock protein as a dendritic cell-targeting molecule: a new strategy to enhance the potency of genetic vaccines

H Hauser, L Shen, QL Gu, S Krueger, SY Chen - Gene therapy, 2004 - nature.com
DNA vaccines are an appealing strategy for inducing cytotoxic T-lymphocyte and antibody
responses against tumor cells as well as infectious agents. Dendritic cells (DCs) play a …

Improved efficacy of DNA vaccination against breast cancer by boosting with the repeat beta-hCG C-terminal peptide carried by mycobacterial heat-shock protein …

H Yi, Y Rong, Z Yankai, L Wentao, Z Hongxia, W Jie… - Vaccine, 2006 - Elsevier
Studies have demonstrated that active-specific immunotherapy has potential for controlling
mammary tumor progression. Human chorionic gonadotropin (hCG) is expressed and …

Development of heat shock proteins with controlled distribution properties and their application to vaccine delivery

M Nishikawa, S Takemoto… - Yakugaku Zasshi: Journal …, 2007 - europepmc.org
Antigen delivery to antigen-presenting cells (APCs) is a key issue in developing effective
cancer vaccines. Controlling the tissue distribution of antigens, which are administered in a …

Screening of cytokines to enhance vaccine effects of heat shock protein 70-rich tumor cell lysate

A Ito, M Fujioka, K Tanaka, T Kobayashi… - Journal of bioscience and …, 2005 - Elsevier
Heat shock proteins (HSPs) have been recognized as significant participants in immune
reactions. We have previously reported that heat-treated cells expressing HSP70 can …

Immunization with a lymphocytic choriomeningitis virus peptide mixed with heat shock protein 70 results in protective antiviral immunity and specific cytotoxic T …

AMT Ciupitu, M Petersson, CL O'Donnell… - The Journal of …, 1998 - rupress.org
Heat shock proteins (hsp's) isolated from murine cancer cells can elicit protective immunity
and specific cytotoxic T lymphocytes (CTLs) by channeling tumor-derived peptides bound to …