18F-FDG PET metabolic-to-morphological volume ratio predicts PD-L1 tumour expression and response to PD-1 blockade in non-small-cell lung cancer

M Jreige, I Letovanec, K Chaba, S Renaud… - European journal of …, 2019 - Springer
Abstract Purpose Anti-PD-1/PD-L1 blockade can restore tumour-specific T-cell immunity and
is an emerging therapy in non-small-cell lung cancer (NSCLC). We investigated the …

PD-L1 expression correlation with metabolic parameters of FDG PET/CT and clinicopathological characteristics in non-small cell lung cancer

X Wu, Y Huang, Q Zhao, L Wang, X Song, Y Li… - EJNMMI research, 2020 - Springer
Background Immunotherapy targeting programmed cell death 1 (PD-1) or its ligand 1 (PD-
L1) has shown promising results in non-small cell lung cancer (NSCLC) patients. Exploring …

The value of 18F-FDG PET/CT in predicting the response to PD-1 blocking immunotherapy in advanced NSCLC patients with high-level PD-L1 expression

K Vekens, H Everaert, B Neyns, B Ilsen, L Decoster - Clinical lung cancer, 2021 - Elsevier
Background The objective of this study was to evaluate if 18 F-fluorodeoxyglucose positron
emission tomography/computed tomography (18 F-FDG PET/CT)-derived parameters are …

Metabolic activity by 18F–FDG-PET/CT is predictive of early response after nivolumab in previously treated NSCLC

K Kaira, T Higuchi, I Naruse, Y Arisaka, A Tokue… - European journal of …, 2018 - Springer
Background Nivolumab, an anti-programmed death-1 (PD-1) antibody, is administered in
patients with previously treated non-small cell lung cancer. However, little is known about …

18F-FDG PET/CT in non-small-cell lung cancer patients: a potential predictive biomarker of response to immunotherapy

L Evangelista, L Cuppari, J Menis… - Nuclear Medicine …, 2019 - journals.lww.com
Aim The aim of this study was to assess the predictive role of fluorine-18-fluorodeoxyglucose
(18 F-FDG) PET/computed tomography (CT) in the evaluation of response to immunotherapy …

Correlation of metabolic information on FDG-PET with tissue expression of immune markers in patients with non-small cell lung cancer (NSCLC) who are candidates …

E Lopci, L Toschi, F Grizzi, D Rahal, L Olivari… - European journal of …, 2016 - Springer
Purpose Eliciting antitumor T-cell response by targeting the PD-1/PD-L1 axis with
checkpoint inhibitors has emerged as a novel therapeutic strategy in non-small cell lung …

Quantification of PD-L1 expression with 18F-BMS-986192 PET/CT in patients with advanced-stage non–small cell lung cancer

MC Huisman, ALN Niemeijer… - Journal of Nuclear …, 2020 - Soc Nuclear Med
The aim of this work was to quantify the uptake of 18F-BMS-986192, a programmed cell
death ligand 1 (PD-L1) adnectin PET tracer, in patients with non–small cell lung cancer. To …

Value of 18F-FDG-PET to predict PD-L1 expression and outcomes of PD-1 inhibition therapy in human cancers

K Kaira, I Kuji, H Kagamu - Cancer Imaging, 2021 - Springer
Abstract Anti-programmed cell death-1 (PD-1)/programmed death ligand-1 (PD-L1)
antibodies are administered in varied human cancer types. The expression of PD-L1 within …

Predictive value of baseline FDG-PET/CT for the durable response to immune checkpoint inhibition in NSCLC patients using the morphological and metabolic features …

K Kudura, N Ritz, T Kutzker, MHK Hoffmann… - Cancers, 2022 - mdpi.com
Simple Summary Lung cancer is the leading cause of cancer-related death worldwide.
Nonsmall cell lung cancer (NSCLC) accounts for 80–85% of all cases. Immune checkpoint …

Predicting PD-L1 expression status in patients with non-small cell lung cancer using [18F]FDG PET/CT radiomics

X Zhao, Y Zhao, J Zhang, Z Zhang, L Liu, X Zhao - EJNMMI research, 2023 - Springer
Background In recent years, immune checkpoint inhibitor (ICI) therapy has greatly changed
the treatment prospects of patients with non-small cell lung cancer (NSCLC). Among the …