聚氧化钒酸盐——治疗神经退行性疾病和衰老疾病的新选择

SI Gonzalez-Cano, G Flores, J Guevara… - 中国神经再生研究 …, 2024 - sjzsyj.com.cn
Aging is a natural phenomenon characterized by a progressive decline in physiological
integrity, leading to a deterioration of cognitive function and increasing the risk of suffering …

Polyoxidovanadates a new therapeutic alternative for neurodegenerative and aging diseases

SI Gonzalez-Cano, G Flores, J Guevara… - Neural Regeneration …, 2023 - journals.lww.com
Aging is a natural phenomenon characterized by a progressive decline in physiological
integrity, leading to a deterioration of cognitive function and increasing the risk of suffering …

Polyoxidovanadates as a pharmacological option against brain aging

A Díaz, R Vázquez-Roque, K Carreto-Meneses… - Journal of Chemical …, 2023 - Elsevier
The world population is aging rapidly, and chronic diseases associated are cardiometabolic
syndrome, cancer, and neurodegenerative diseases. Oxidative stress and inflammation are …

The protective effect of vanadium on cognitive impairment and the neuropathology of Alzheimer's disease in APPSwe/PS1dE9 mice

Z He, S Han, H Zhu, X Hu, X Li, C Hou, C Wu… - Frontiers in Molecular …, 2020 - frontiersin.org
Alzheimer's disease (AD) is a widely distributed neurodegenerative disease characterized
clinically by cognitive deficits and pathologically by formation of amyloid-β (Aβ) plaque and …

Bis(ethylmaltolato)oxidovanadium(iv) inhibited the pathogenesis of Alzheimer's disease in triple transgenic model mice

Z He, S Han, C Wu, L Liu, H Zhu, A Liu, Q Lu… - Metallomics, 2020 - academic.oup.com
Vanadium compounds have been reported to mimic the anti-diabetes effects of insulin on
rodent models, but their effects on Alzheimer's disease (AD) have rarely been explored. In …

Alzheimer's disease and diabetes mellitus in comparison: The therapeutic efficacy of the vanadium compound

Z He, G You, Q Liu, N Li - International Journal of Molecular Sciences, 2021 - mdpi.com
Alzheimer's disease (AD) is an intractable neurodegenerative disease that leads to
dementia, primarily in elderly people. The neurotoxicity of amyloid-beta (Aβ) and tau protein …

An Adequate Supply of Bis (ethylmaltolato) oxidovanadium (IV) Remarkably Reversed the Pathological Hallmarks of Alzheimer's Disease in Triple-Transgenic Middle …

Z He, L Zheng, X Zhao, X Li, H Xue, Q Zhao… - … Trace Element Research, 2022 - Springer
Alzheimer's disease (AD) is a complex and progressive neurodegenerative disease with
impaired synapse, imbalanced mineral metabolism, protein mis-folding and aggregation. Bis …

Anti-diabetic vanadyl complexes reduced Alzheimer's disease pathology independent of amyloid plaque deposition

Y Dong, T Stewart, Y Zhang, M Shi, C Tan, X Li… - Science China Life …, 2019 - Springer
Association of Alzheimer's disease (AD) with cerebral glucose hypometabolism, likely due to
impairments of insulin signaling, has been reported recently, with encouraging results when …

The deficits of insulin signal in Alzheimer's disease and the mechanisms of vanadium compounds in curing AD

J Yao, Z He, G You, Q Liu, N Li - Current Issues in Molecular Biology, 2023 - mdpi.com
Vanadium is a well-known essential trace element, which usually exists in oxidation states in
the form of a vanadate cation intracellularly. The pharmacological study of vanadium began …

Synthesis and anti-diabetic activity of new N, N-dimethylphenylenediamine-derivatized nitrilotriacetic acid vanadyl complexes

X Niu, J Yang, X Yang - Journal of Inorganic Biochemistry, 2017 - Elsevier
Vanadium compounds are promising anti-diabetic agents. However, reducing the metal
toxicity while keeping/improving the hypoglycemic effect is still a big challenge towards the …