脊髓损伤亚急性期较低剂量二甲双胍治疗可改善功能预后
WY Song, H Ding, T Dunn, JL Gao… - 中国神经再生研究 …, 2021 - sjzsyj.com.cn
二甲双胍是治疗2 型糖尿病的一线药物, 有研究显示其可促进脊髓损伤后运动能力的恢复,
但也有研究显示没有积极的作用. 作者在预实验中发现高剂量(200 mg/kg) …
但也有研究显示没有积极的作用. 作者在预实验中发现高剂量(200 mg/kg) …
Low-dose metformin treatment in the subacute phase improves the locomotor function of a mouse model of spinal cord injury
WY Song, H Ding, T Dunn, JL Gao… - Neural Regeneration …, 2021 - journals.lww.com
Metformin, a first-line drug for type-2 diabetes, has been shown to improve locomotor
recovery after spinal cord injury. However, there are studies reporting no beneficial effect …
recovery after spinal cord injury. However, there are studies reporting no beneficial effect …
二甲双胍促进老年小鼠脊髓损伤后血管生成和功能恢复
JY Zhao, XL Sheng, CJ Li, T Qin, RD He… - 中国神经再生研究 …, 2023 - sjzsyj.com.cn
二甲双胍治疗可恢复脊髓损伤后广泛的生物活性, 但其是否也对老年小鼠的脊髓损伤有作用,
目前仍不清楚. 考虑到血管生成在再生过程中的重要作用, 实验假设二甲双胍可通过激活内皮 …
目前仍不清楚. 考虑到血管生成在再生过程中的重要作用, 实验假设二甲双胍可通过激活内皮 …
二甲双胍减轻脊髓损伤: 上调血红素加氧酶1 以抑制神经细胞铁死亡
Z Wang, W Zhou, Z Zhang, L Zhang, M Li - 中国神经再生研究(英文版), 2024 - sjzsyj.com.cn
既往研究发现血红素加氧酶1 可在多种中枢神经系统损伤模型中上调, 且其具有抗炎作用,
并在调节细胞氧化还原稳态方面至关重要. 二甲双胍是一种治疗2 型糖尿病的经典药物 …
并在调节细胞氧化还原稳态方面至关重要. 二甲双胍是一种治疗2 型糖尿病的经典药物 …
[PDF][PDF] Research Article Effect of Metformin on Locomotor Function Recovery in Rat Spinal Cord Injury Model: A Meta-analysis
Q Chen, D Xie, Q Yao, L Yang - 2021 - academia.edu
Background. Disorder of locomotor function is universal in patients with spinal cord injury
(SCI) and has a severe impairment on their quality of life. Metformin, the first-line antidiabetic …
(SCI) and has a severe impairment on their quality of life. Metformin, the first-line antidiabetic …
Delayed metformin treatment improves functional recovery following traumatic brain injury via central AMPK-dependent brain tissue repair
YY Fan, YJ Wang, J Guo, MN Wu, MS Zhang… - Brain Research …, 2020 - Elsevier
Accumulating evidence suggests that chronic metformin posttreatment offers potent
neuroreparative effects against acute brain injury. However, in previous studies, metformin …
neuroreparative effects against acute brain injury. However, in previous studies, metformin …
Metformin promotes microglial cells to facilitate myelin debris clearance and accelerate nerve repairment after spinal cord injury
Y Wu, J Xiong, Z He, Y Yuan, B Wang, J Xu… - Acta Pharmacologica …, 2022 - nature.com
Spinal cord injury (SCI) is one kind of severe trauma for central nervous system. Myelin
debris clearance and axon regeneration are essential for nerve regeneration after SCI …
debris clearance and axon regeneration are essential for nerve regeneration after SCI …
Effect of Metformin on Locomotor Function Recovery in Rat Spinal Cord Injury Model: A Meta‐analysis
Q Chen, D Xie, Q Yao, L Yang - Oxidative Medicine and …, 2021 - Wiley Online Library
Background. Disorder of locomotor function is universal in patients with spinal cord injury
(SCI) and has a severe impairment on their quality of life. Metformin, the first‐line …
(SCI) and has a severe impairment on their quality of life. Metformin, the first‐line …
人体等效剂量4-氨基吡啶灌胃给药可区分小鼠坐骨神经损伤类型并改善其功能
CG Hsu, MAH Talukder, L Yue, LC Turpin… - 中国神经再生研究 …, 2020 - sjzsyj.com.cn
4-氨基吡啶是FDA 批准的用于多发性硬化症治疗的药物, 可改善患者的神经肌肉功能.
我们最近的研究证明, 4-氨基吡啶的局部, 透皮或注射形式可改善小鼠创伤性周围神经损伤后的 …
我们最近的研究证明, 4-氨基吡啶的局部, 透皮或注射形式可改善小鼠创伤性周围神经损伤后的 …