Salsalate alleviates hyperglycemia by inhibiting endoplasmic reticulum stress in high fat diet induced obese mice

XL YUAN - Academic Journal of Second Military Medical …, 2018 - pesquisa.bvsalud.org
Objective To explore the effect of salsalate on the glucose metabolism of obese mice
induced with high fat diet (HFD). Methods Eight week-old male C57BL/6J mice were fed with …

Effect of salsalate on metabolic syndrome-related parameters and activity of brown adipose tissue in Wistar and hereditary hypertriglyceridemic rats

V Skop, J Trnovska, M Huttl, H Malinska… - …, 2016 - atherosclerosis-journal.com
Objectives: Salsalate is a nonacetylated form of salicylate and belongs to the non-steroidal
anti-inflammatory drugs. Besides of its effect on inflammation, salsalate also beneficially …

[HTML][HTML] Salsalate activates skeletal muscle thermogenesis and protects mice from high-fat diet induced metabolic dysfunction

L Nie, XL Yuan, KT Jiang, YH Jiang, J Yuan, L Luo… - …, 2017 - thelancet.com
Salsalate plays beneficial roles for ameliorating hyperglycemia and dyslipidemia in type 2
diabetes patients, but the underlying mechanisms are still poorly understood. In this study …

[HTML][HTML] Hypolipidemic and insulin sensitizing effects of salsalate beyond suppressing inflammation in a prediabetic rat model

M Hüttl, I Markova, D Miklánková… - Frontiers in …, 2023 - frontiersin.org
Background and aims: Low-grade chronic inflammation plays an important role in the
pathogenesis of metabolic syndrome, type 2 diabetes and their complications. In this study …

[图书][B] Analysis of transition from pre-diabetes to diabetes in two animal models and evaluation of anti-diabetic effects of salsalate

X Wang - 2014 - search.proquest.com
Type 2 diabetes, once called non-insulin-dependent diabetes, is the most common form of
diabetes worldwide. It is characterized by insulin resistance and progressive beta cell …

Salsalate activates brown adipose tissue in mice

AD Van Dam, KJ Nahon, S Kooijman… - Diabetes, 2015 - Am Diabetes Assoc
Salsalate improves glucose intolerance and dyslipidemia in type 2 diabetes patients, but the
mechanism is still unknown. The aim of the current study was to unravel the molecular …

[HTML][HTML] Salsalate ameliorates metabolic disturbances by reducing inflammation in spontaneously hypertensive rats expressing human C-reactive protein and by …

J Trnovska, J Šilhavý, O Kuda, V Landa, V Zidek… - PLoS …, 2017 - journals.plos.org
Chronic low-grade inflammation plays an important role in the pathogenesis of insulin
resistance. In the current study, we tested the effects of salsalate, a non-steroidal anti …

[HTML][HTML] Preventive role of salsalate in diabetes is associated with reducing intestinal inflammation through improvement of gut dysbiosis in ZDF rats

X Zhang, X Cui, X Jin, F Han, J Wang, X Yang… - Frontiers in …, 2020 - frontiersin.org
A safe and effective approach is needed to prevent and reduce the incidence of diabetes
worldwide. The hypoglycemic efficacy of salicylic acid (salsalate, SAL), which has anti …

[HTML][HTML] Salidroside improves glucose homeostasis in obese mice by repressing inflammation in white adipose tissues and improving leptin sensitivity in …

M Wang, L Luo, L Yao, C Wang, K Jiang, X Liu, M Xu… - Scientific Reports, 2016 - nature.com
Salidroside is a functionally versatile natural compound from the perennial flowering plant
Rhodiola rosea L. Here, we examined obese mice treated with salidroside at the dosage of …

Salsalate treatment improves glycemia without altering adipose tissue in nondiabetic obese hispanics

TL Alderete, FR Sattler, JM Richey, H Allayee… - …, 2015 - Wiley Online Library
Objective Salsalate treatment has well‐known effects on improving glycemia, and the
objective of this study was to examine whether the mechanism of this effect was related to …