诱导多能干细胞衍生的脑细胞, 类器官, 组装体和血脑屏障模型在理解酒精和麻醉剂诱导的脑损伤中的应用: 一个新的视角

X Bai - 中国神经再生研究(英文版), 2024 - sjzsyj.com.cn
Neurological disorders, including developmental disorders, Alzheimer's disease (AD), and
psychiatric conditions, have significant social and economic impacts globally. Despite …

[HTML][HTML] Use of induced pluripotent stem cell-derived brain cells, organoids, assembloids, and blood-brain barrier models in understanding alcohol and anesthetic …

X Bai - Neural Regeneration Research, 2024 - journals.lww.com
Neurological disorders, including developmental disorders, Alzheimer's disease (AD), and
psychiatric conditions, have significant social and economic impacts globally. Despite …

Modeling alcohol-induced neurotoxicity using human induced pluripotent stem cell-derived three-dimensional cerebral organoids

T Arzua, Y Yan, C Jiang, S Logan, RL Allison… - Translational …, 2020 - nature.com
Maternal alcohol exposure during pregnancy can substantially impact the development of
the fetus, causing a range of symptoms, known as fetal alcohol spectrum disorders (FASDs) …

Using human stem cells as a model system to understand the neural mechanisms of alcohol use disorders: current status and outlook

MS Scarnati, A Halikere, ZP Pang - Alcohol, 2019 - Elsevier
Alcohol use disorders (AUDs), which include alcohol abuse and dependence, are among
the most common types of neuropsychiatric disorders in the United States (US) …

Postmortem-derived iPSC models in substance use disorders research

EF Mendez, C Walss-Bass - Neuropsychopharmacology, 2024 - nature.com
Patient-derived induced pluripotent stem cell (iPSC) models have accelerated discovery in
the biomedical sciences, with high potential to model human physiology and disease. The …

High-content analysis for ethanol-induced mitochondrial and neuronal toxicity in human iPSC-derived neurons

A Zink - 2021 - refubium.fu-berlin.de
Ethanol is the most frequently abused drug in the world with a worldwide mortality of three
million deaths each year (5.3% in 2016). Excessive ethanol consumption can adversely …

Utilizing human induced pluripotent stem cells in the study of alcohol use disorder

R Lieberman - 2016 - digitalcommons.lib.uconn.edu
Alcohol use disorder is a complex, heterogeneous disorder that affects≈ 14% of the US
population. Much of what is known about the molecular effects of alcohol on the brain has …

Recent advances in 3D-cultured brain tissue models derived from human iPSCs

NY Choi, MY Lee, S Jeong - BioChip Journal, 2022 - Springer
Neurological diseases are caused by defects in the brain, spinal cord, or nervous system.
Excluding animal models, ex vivo brain tissues and brain organoids have been used for …

Alcohol-responsive genes identified in human iPSC-derived neural cultures

KP Jensen, R Lieberman, HR Kranzler… - Translational …, 2019 - nature.com
Alcohol use contributes to numerous diseases and injuries. The nervous system is affected
by alcohol in diverse ways, though the molecular mechanisms of these effects are not clearly …

[HTML][HTML] Studying human neurological disorders using induced pluripotent stem cells: from 2D monolayer to 3D organoid and blood brain barrier models

S Logan, T Arzua, SG Canfield… - Comprehensive …, 2019 - ncbi.nlm.nih.gov
Neurological disorders have emerged as a predominant healthcare concern in recent years
due to their severe consequences on quality of life and prevalence throughout the world …