跨膜肽聚乙二醇-脂质体可跨越血脊髓屏障及血脑屏障

X Zhou, C Wang, S Feng, J Chang, X Kong… - 中国神经再生研究(英文 …, 2012 - sjzsyj.com.cn
Naive liposomes can cross the blood-brain barrier and blood-spinal cord barrier in small
amounts. Liposomes modified by a transactivating-transduction protein can deliver …

Transactivating-transduction protein-polyethylene glycol modified liposomes traverse the blood-spinal cord and blood-brain barriers☆

X Zhou, C Wang, S Feng, J Chang… - Neural Regeneration …, 2012 - journals.lww.com
Naive liposomes can cross the blood-brain barrier and blood-spinal cord barrier in small
amounts. Liposomes modified by a transactivating-transduction protein can deliver …

Development of DDS actively to overcome the blood-brain barrier in the region of ischemic stroke

T Fukuta, K Kogure - … Zasshi: Journal of the Pharmaceutical Society …, 2020 - europepmc.org
We previously showed that increased permeability of the blood-brain barrier (BBB) after
ischemic stroke enables extravasation of nano-sized liposomes and accumulation in the …

Grafting of cell-penetrating peptide to receptor-targeted liposomes improves their transfection efficiency and transport across blood–brain barrier model

G Sharma, A Modgil, C Sun, J Singh - Journal of pharmaceutical sciences, 2012 - Elsevier
We report bifunctional liposomal delivery system, combining transferrin (Tf)-mediated
receptor targeting and poly-l-arginine (PR)-facilitated cell penetration, which overcomes the …

Liposome targeting to rat brain: effect of osmotic opening of the blood-brain barrier

A Sakamoto, T Ido - Brain research, 1993 - Elsevier
To determine whether sulfatide liposomes can cross the blood-brain barrier (BBB) with or
without osmotic treatment by mannitol, we administered liposomes through the internal …

Development of Biomembrane-mimetic Nanoparticles for the Treatment of Ischemic Stroke

T Fukuta - Yakugaku Zasshi: Journal of the Pharmaceutical …, 2021 - europepmc.org
Increase in vascular permeability of the blood-brain barrier (BBB) is a distinct pathology
following ischemic stroke. In previous studies, we demonstrated that liposomal drug delivery …

Angiopep-2 and transferrin co-modified liposome for targeted drug delivery across the blood-brain barrier

X DONG - Academic Journal of Second Military Medical …, 2014 - pesquisa.bvsalud.org
Objective To prepare angiopep-2 and transferrin co-modified liposomes (ANG/TF-LPs) and
to observe their propertyof passing the blood-brain barrier (BBB). Methods ANG/TF-LPs …

Targeting of post-ischemic cerebral endothelium in rat by liposomes bearing polyethylene glycol-coupled transferrin

N Omori, K Maruyama, G Jin, SJ Wang… - Neurological …, 2003 - Taylor & Francis
To achieve an efficient delivery targeting to post-ischemic cerebral vascular endothelium,
PEG-liposome conjugated with transferrin (Tf)(Tf-PEG-liposome) was intravenously …

Liposome-encapsulated brain-derived neurotrophic factor targets blood-brain barrier

G Zhang - Chinese Journal of Immunology, 2017 - pesquisa.bvsalud.org
Objective: To observe the characteristics of the tissue distribution of the blood brain barrier
through the modification of the liposome encapsulated brain derived neurotrophic factor …

Lactoferrin-modified procationic liposomes as a novel drug carrier for brain delivery

H Chen, L Tang, Y Qin, Y Yin, J Tang, W Tang… - European Journal of …, 2010 - Elsevier
In this study, a new drug carrier for brain delivery, lactoferrin-modified procationic liposome,
was developed and evaluated in vitro and in vivo. The procationic liposomes (PCLs) were …