The hot direction of life science is to explore the development mechanism of malignant
tumor. Recent studies have shown that, in tumor formation, whether in vivo or in vitro …

Gadd45 protein is a stress protein that responds to the environment and plays an important
role in the regulation of various cell functions such as DNA repair, cell cycle and senescence …

Mammalian cells are prone to tumorigenesis when suffering the genotoxic stresses, and the
existence of the tumor suppressors validly decrease this possibility. Gadd45α is one of the …

Gadd45a, a p53 and BRCA1-regulated growth arrest and DNA damage gene, plays
important roles in suppressing cell transformation and tumor malignancy. Gadd45a …

The stress response gadd45 gene family participates in cell cycle control, cell survival,
apoptosis, maintenance of genomic stability, DNA repair, and active DNA demethylation, in …

Growth Arrest and DNA-damage-inducible, alpha (GADD45α) is a member of the GADD
family proteins that also include GADD45β and GADD45γ. The highly conserved GADD45 …

Objective: GADD45A is a growth arrest-associated gene, directly involved in the
maintenance of genomic stability. In fact, in the absence of this protein cells became …

The Growth Arrest and DNA Damage-inducible 45 (GADD45) proteins have been implicated
in regulation of many cellular functions including DNA repair, cell cycle control, senescence …

Growth-arrest and DNA-damage inducible (GADD) genes and Myeloid differentiation
primary response (MyD) genes represent a family of genes that play a key role in negative …

Regulation of cell cycle and growth is integral for cell survival. The intricate mechanisms that
control proliferation and cell cycle are numerous. The growth arrest and DNA damage …