To date, pancreatic cancer remains one of the most lethal and least understood tumors
known and is characterized as being resistant to most conventional chemotherapeutic …

To identify apoptosis genes involved in the multidrug resistance of osteosarcoma, a
multidrug resistant human osteosarcoma cell line (U-2 OS MR) was established. Apoptosis …

Gadd45 expression, which is stress inducible, has been associated with growth arrest, but
the exact role of gadd45 family genes in apoptosis still remains unclear. We have found that …

Growth arrest and DNA damage-inducible (GADD) 45 proteins are regulators of cell death
and survival. The proinflammatory cytokine IL-1β strongly increases the level of the transcript …

NSO myeloma cells are a major host cell line used for the expression of industrially-relevant
recombinant proteins. However, apoptosis, or programmed cell death, during culture may …

Growth arrest and DNA damage 45-α (GADD45-α) is a nuclear protein involved in
maintenance of genomic stability, DNA repair, and suppression of cell growth through …

The NF-κB/IκB signaling pathway is a critical regulator of cell survival in cancer. Here, we
report that combined down-regulation of growth arrest-and DNA-damage-inducible proteins …

GADD45 genes are epigenetically inactivated in various types of cancer and tumor cell
lines. To date, defects of the GADD45 gene family have not been implicated in …

Background: This study focussed on exploring the prognostic prediction performance of the
growth arrest and DNA damage-inducible 45 beta (GADD45B) and its associations with T …

A new GADD45α isoform, GADD45α1, was identified in the cellular response to arsenic.
DNA sequencing and biochemical analyses suggested that GADD45α1 is derived from an …