VKORC1 Haplotypes Are Associated With Arterial Vascular Diseases (Stroke, Coronary Heart Disease, and Aortic Dissection)

Y Wang, W Zhang, Y Zhang, Y Yang, L Sun, S Hu… - Circulation, 2006 - Am Heart Assoc
Background—The haplotypes in the gene vitamin K epoxide reductase complex subunit 1
(VKORC1) have been found to affect warfarin dose response through effects on the …

Lack of association between variants in the VKORC1 gene and cerebrovascular or coronary heart disease

R Lemmens, S Abboud, L Vanhees, A Goris… - Journal of Thrombosis …, 2008 - jthjournal.org
Cerebrovascular disease (CVD) and coronary heart disease (CHD) can be considered to be
complex diseases, where several genetic polymorphisms, together with known and …

Frequencies of VKORC1‐1639G> A and rs397509427 in Patients on Warfarin and Healthy Syrian Subjects

Y Altawil, LA Youssef - Cardiovascular Therapeutics, 2023 - Wiley Online Library
Background. Vitamin K epoxide reductase complex subunit 1 (VKORC1) gene encodes a
key enzyme with multiple cellular activities, namely, the reduction of vitamin K to its active …

Association Between VKORC1 Gene Polymorphisms and Ischemic Cerebrovascular Disease in Chinese Han Population

H Zhang, L Yang, Q Feng, Y Fan, H Zheng… - Journal of Molecular …, 2014 - Springer
The vitamin K epoxide reductase subunit 1 gene (VKORC1) plays a key role in vitamin K
recycling, and there is a close association between VKORC1 gene single-nucleotide …

Functional promoter polymorphism in the VKORC1 gene is no major genetic determinant for coronary heart disease in Northern Germans

M Watzka, A Nebel, NE El Mokhtari… - Thrombosis and …, 2007 - thieme-connect.com
Recently, the C-allele of polymorphism rs2359612 (VKORC1: c. 283+ 837C> T) in the
VKORC1 gene has been reported to represent a major risk factor for coronary heart disease …

Common VKORC1 variants are not associated with arterial or venous thrombosis

LA Hindorff, SR Heckbert, N Smith… - Journal of Thrombosis …, 2007 - jthjournal.org
The vitamin K epoxide receptor complex subunit 1 (VKORC1) plays a crucial role in the
regulation of several vitamin K-dependent proteins relevant to hemostasis and, perhaps …

Single nucleotide polymorphisms in the VKORC1 gene and the risk of stroke in the Southern German population

ML Arnold, C Lichy, I Werner… - Thrombosis and …, 2008 - thieme-connect.com
Variation in the gene that encodes the vitamin K epoxide reductase subunit 1 (VKORC1)
was recently proposed as a genetic risk factor for stroke in a Chinese population. In this …

[HTML][HTML] Vitamin K epoxide reductase genetic polymorphism is associated with venous thromboembolism: results from the EDITH Study

K Lacut, C Larramendy‐Gozalo, G Le Gal… - Journal of Thrombosis …, 2007 - Elsevier
Background: The vitamin K epoxide reductase complex subunit 1 (VKORC1) recycles
endogenous vitamin K, a cofactor for vitamin K‐dependent coagulation factor synthesis …

VKORC1 rs2359612C allele is associated with increased risk of coronary artery disease in the presence of coronary calcification

Y Wang, J Chen, Y Zhang, L Bin, K Sun, W Yu, J Liu… - Human genetics, 2013 - Springer
VKORC1 genetic polymorphisms affect warfarin dose response, aortic calcification, and the
susceptibility of coronary artery disease as shown in our previous study. Little is known …

[PDF][PDF] VKORC1 rs2359612 and rs9923231 polymorphisms correlate with high risks of cardiovascular and cerebrovascular diseases

Y Li, J Zhu, JQ Ding - Genetics and Molecular Research, 2015 - funpecrp.com.br
We aimed to confirm the correlations between rs2359612 and rs9923231 single nucleotide
polymorphisms (SNPs) in the vitamin K epoxide reductase complex subunit 1 (VKORC1) …